角膜基质透镜在角膜溃疡或穿孔修复中的应用  

Repair of corneal ulcer or perforation using the corneal stromal lenticule

作　　者：郝晓凤[1] 谢立科[1] 张京[1] 张志芳[1] 秦睿[1] 祁怡馨 明静[1] 张小艳 李萱 李晓宇 孙会兰[1] Xiao-Feng Hao;Li-Ke Xie;Jing Zhang;Zhi-Fang Zhang;Rui Qin;Yi-Xin Qi;Jing Ming;Xiao-Yan Zhang;Xuan Li;Xiao-Yu Li;Hui-Lan Sun(Eye Hospital,China Academy of Chinese Medical Sciences,Beijing 100040,China)

机构地区：[1]中国中医科学院眼科医院,中国北京市100040

出　　处：《国际眼科杂志》2018年第1期150-152,共3页International Eye Science

摘　　要：目的:研究由全飞秒激光SMILE手术所得的角膜基质透镜作为角膜移植材料治疗角膜溃疡的临床疗效。方法:回顾性病例研究。收集本院2017-01/06角膜溃疡患者6例6眼,其中细菌性、真菌性、深层异物伴感染各1例1眼,角膜穿孔3例3眼。采用由全飞秒激光SMILE手术所得的角膜基质透镜作为角膜移植的材料进行修复手术,确保植片与角膜层间无空气间隙。术后随访1~6(平均3.71±1.56)mo,观察手术前后视力、角膜移植物存活情况及术后并发症发生情况等。结果:所有患者均在控制感染下顺利完成手术,无术中并发症。术后所有角膜植片透明。末次随访时,患者最佳矫正视力(best corrected visual acuity,BCVA)较术前明显改善(0.48±0.12 vs 1.50±0.08),差异具有统计学意义(P<0.01)。结论:来源于全飞秒激光屈光手术的角膜基质透镜用于角膜溃疡修复是安全有效的,但植片的远期疗效尚需进一步观察。AIM:To describe the outcomes of corneal stromal lenticules in repairing of corneal ulcer and/or perforation.METHODS:This was a retrospective chart review of6eyes of6patients from January to June2017.who underwent corneal ulcer repair with the corneal,stromal lenticules harvested from femtosecond laser refractive surgery and kept in pure glycerin for use.Three cases of infectious corneal ulcers were bacterial,fungal,and infection with foreign bodies in corneal deep layer,one each.The other3were corneal ulcer perforation.Making sure no air bubble between donor graft and Descemet membrane.The mean follow-up time was3.71±1.56mo(range1-6mo).RESULTS:All eyes were successfully treated under control of infection without intra-operative complications,and early postoperative evaluation showed a clear graft in all cases.The last follow-up visit showed the mean best corrected visual acuity(VA)significantly improved after surgery.There was significant difference from0.48±0.12to1.50±0.08(P<0.01).CONCLUSION:The preliminary results suggest that the use of corneal stromal lenticules may be a safe and effective surgical alternative for corneal ulcer,even though the long-term outcome of the graft needs to be further observed.

关 键 词：角膜感染 角膜溃疡 角膜穿孔 角膜基质透镜 角膜移植 

分 类 号：R779.6[医药卫生—眼科]