宫内生长发育迟缓和早产儿视网膜病变的关系研究  

Relationship of intrauterine growth retardation and retinopathy of prematurity

作　　者：彭铎[1] 鲁曦婷[1] 李之喆[1] 顾文婷 王蕾 刘婕 耿宁[1] 顾永辉[1] 王珍[1] Duo Peng;Xi-Ting Lu;Zhi-Zhe Li;Wen-Ting Gu;Lei Wang;Jie Liu;Ning Geng;Yong-Hui Gu;Zhen Wang(Department of Ophthalmology,Suzhou Municipal Hospital,Suzhou 215002,Jiangsu Province,China)

机构地区：[1]中国江苏省苏州市立医院眼科,215002

出　　处：《国际眼科杂志》2018年第1期163-165,共3页International Eye Science

摘　　要：目的:探讨宫内生长发育迟缓(intrauterine growth retardation,IUGR)和早产儿视网膜病变(retinopathy of prematurity,ROP)发病率的关系。方法:对2011-01/2015-12在苏州市立医院新生儿病房及门诊接收的符合ROP筛查标准的儿童2527例5054眼,按照胎龄分为4组(≤32周,>32周且≤34周,>34周且≤37周,>37周),每组再根据出生体质量分为IUGR组和非IUGR组,分别比较每个孕周组中IUGR组和非IUGR组ROP发病率的差异。结果:所有受检2527例患儿中,IUGR共702例,其中ROP患儿78例,非IUGR共1825例,其中ROP 329例。≤32周胎龄组991例中,IUGR组共63例,其中ROP 27例(42.9%),非IUGR组共928例,其中ROP 274例(29.5%),IUGR的ROP发病率高于非IUGR组,差异有统计学意义(χ~2=4.958,P=0.026)。>32周且≤34周胎龄组1025例中,IUGR共232例,其中ROP 33例(14.2%);非IUGR共793例,其中ROP 51例(6.4%),IUGR的ROP发病率高于非IUGR组,差异有统计学意义(χ~2=14.488,P<0.001)。>34周且≤37周胎龄组464例中,IUGR共374例,其中ROP 18例(4.8%);非IUGR共90例,其中ROP 4例(4.4%),IUGR的ROP发病率略高于非IUGR组,但差异无统计学意义(P=1)。>37周胎龄组47例中,IUGR共33例,非IUGR共14例,均无ROP发病患儿。结论:IUGR和ROP的发病密切相关,胎龄≤34周的早产儿中,IUGR的患儿ROP的发病率明显高于非IUGR的患儿。AIM:To analyze the association of intrauterine growth retardation(IUGR)and retinopathy of prematurity(ROP).METHODS:A retrospective analysis of a case series included in ROP screening from January2011to December2015was performed in Suzhou Municipal Hospital.Totally2527children(5054eyes)underwent screening.According to the gestational age,the data was divided into4groups(≤32wk,>32and≤34wk,>34and≤37wk,>37wk).Every group was divided into two groups(IUGR group and no IUGR group)respectively.We compared the incidence of ROP in IUGR and non IUGR group.RESULTS:Of all the2527children,IUGR group were702including78ROP children,and non IUGR group were1825including329ROP children.There were991children were divided into32wk group,including63IUGR in which27children were screened out ROP(42.9%)and928non IUGR in which274children were screened out ROP(29.5%),the difference on the incidence of ROP was statistically significant(x2=4.958,P=0.026).There were1025children were divided into>32and≤34wk group,including232IUGR in which33children were screened out ROP(14.2%)and793non IUGR in which51children were screened out ROP(6.4%)and the difference was statistically significant(x2=14.488,P<0.001).There were464children were divided into>34and≤37wk group,including374IUGR in which18children were screened out ROP(4.8%)and90non IUGR in which4children were screened out ROP(4.4%)and the difference was not statistically significant(Fischer exact test,P=1).There were47children were divided into>37wk group,including33IUGR and14non IUGR,none were screened out in the two groups.CONCLUSION:Intrauterine growth retardation was closely related to the incidence of ROP.In the preterm infants with gestational age less than34wk.the incidence of ROP in children with intrauterine growth retardation is significantly higher than that in children without intrauterine growth retardation.

关 键 词：早产儿视网膜病变 宫内生长发育迟缓 出生体质量 胎龄 

分 类 号：R774.1[医药卫生—眼科]