自噬相关基因Atg7 rs11706903单核苷酸多态性与帕金森病的相关性  

Association of Single Nucleotide Polymorphisms of Autophagy-related Genes Atg7 Site rs11706903 and Parkinson's Disease

作　　者：贺鹏[1] 赵西耀[2] 陈煜森 陈霄仪 郑伟明[1] HE Peng;ZHAO Xi-yao;CHEN Yu-sen;CHEN Xiao-yi;ZHENG Wei-ming(Department of Neurology, Guangdong General Hospital's Nanhai Hospital (the Second People's Hospital of Nanhai District Foshan City), Foshan, Guangdong 528251, China;Department of Neurology, the Second Affiliated Hospital (Jiande Branch), School of Medicine, Zhejiang University, Hangzhou, Zhejiang 311600, China;Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 52400l, China)

机构地区：[1]广东省人民医院南海医院(佛山市南海区第二人民医院)神经内科,广东佛山市528251 [2]浙江大学医学院附属第二医院建德分院神经内科,浙江建德市311600 [3]广东医科大学附属医院神经内科,广东湛江市524001

出　　处：《中国康复理论与实践》2017年第11期1313-1316,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：杭州市医疗卫生科研项目(No.20150633B82)

摘　　要：目的研究Atg7内含子区rs11706903单核苷酸多态性与帕金森病的关系。方法 2013年1月至2017年3月,收集130例帕金森病患者(病例组)和同期109例健康体检者(对照组)血样,采用聚合酶链反应-限制性片段长度多态性分析方法检测Atg7rs11706903基因多态性。结果 rs11706903位点各基因型病例组基因型频率AA 10.00%、AC 52.31%、CC 37.69%,等位基因频率A 36.15%、C 63.85%;对照组基因型频率AA 7.34%、AC 49.54%、CC 43.12%,等位基因频率A 32.11%、C 67.89%。两组间无显著性差异(χ~2<1.001,P>0.05)。结论 Atg7内含子区rs11706903单核苷酸多态性与帕金森病可能无关。Objective To investigate the relationship between the single nucleotide polymorphisms(SNP)of rs11706903,intron region of Atg7,and Parkinson's disease(PD).Methods From January,2013to March,2017,130PD patients and109healthy subjects were recruited and collected the blood samples.SNPs of rs11706903were detected with polymerase chain reaction restriction fragment length polymorphism.Results For the patients,the genotype frequencies of rs11706903were AA10.00%,AC52.31%and CC37.69%;and allele frequencies were A36.15%and C63.85%.For the healthy controls,the genotype frequencies of rs11706903were AA7.34%,AC49.54%and CC43.12%;and allele frequencies were A32.11%and C67.89%.There was no significant difference in frequencies of genetypes and alleles beteen two groups(χ2<1.001,P>0.05).Conclusion There might be no relationship between SNPs of Atg7intron region rs11706903and PD.

关 键 词：帕金森病 自噬相关基因 内含子 单核苷酸多态性 rs11706903 

分 类 号：R742.5[医药卫生—神经病学与精神病学]