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作 者:管付娟 GUAN Fu juan(Department of Obstetrics and Gynecology, People's Hospital of Gong'an County, Jingzhou City, Hubei Province, Jingzhou 434300, China)
机构地区:[1]湖北省荆州市公安县人民医院妇产科,湖北荆州434300
出 处:《海南医学院学报》2017年第17期2404-2407,共4页Journal of Hainan Medical University
基 金:湖北省荆州市科技攻关项目(20152EF3-1)~~
摘 要:目的:探讨同步放化疗对子宫内膜癌术后患者血清肿瘤标志物、血管内皮生长因子(VEGF)、基质金属蛋白酶-9(MMP-9)及炎性因子水平的影响。方法 :以86例行手术治疗的子宫内膜癌患者作为研究对象,随机分为对照组(n=42)和观察组(n=44),两组患者均接受全子宫及双侧附件切除术治疗,在此基础上,对照组采取单纯放疗方案治疗,观察组接受同步放化疗方案治疗,比较两组治疗前后血清肿瘤标志物、VEGF、MMP-9及炎性因子水平。结果:观察组与对照组治疗前CA-125、HE4、VEGF、MMP-9、TNF-α、CRP及IL-6水平比较,差异无统计学意义(P>0.05);治疗后,两组CA-125、HE4、VEGF、MMP-9、TNF-α、CRP及IL-6水平较组内治疗前均显著降低,差异有统计学意义(P<0.05);观察组治疗后CA-125、HE4、VEGF、MMP-9、TNF-α、CRP及IL-6水平均显著低于对照组,差异有统计学意义(P<0.05)。结论:同步放化疗方案治疗可有效降低子宫内膜癌术后患者血清肿瘤标志物、VEGF、MMP-9水平,减轻机体炎性应激反应,具有重要价值。Objective:To investigate the effects of concurrent chemoradiotherapy on serum tumor markers,vascular endothelial growth factor(VEGF),matrix metalloproteinase9(MMP9)and inflammatory factors in patients with endometrial carcinoma after operation.Methods:86patients with endometrial carcinoma treated by surgery were selected as objects of study,according to random data table they were divided into control group(n=42)and observation group(n=44),patients of the two groups were all underwent hysterectomy and bilateral adnexectomy treatment,on this basis,the control group took radiotherapy treatment,observation group patients received concurrent chemotherapy treatment,the levels of serum tumor markers,VEGF,MMP9and inflammatory factor of the two groups before and after treatment were compared.Results:Before treatment,there was no significant difference in CA125,HE4,VEGF,MMP9,TNFα,CRP and IL6levels between the observation group and the control group(P>0.05);After treatment,the levels of CA125,HE4,VEGF,MMP9,TNFα,CRP and IL6in the two groups were significantly lower than those in the group before treatment,and the difference was statistically significant(P<0.05);After treatment,the levels of CA125,HE4,VEGF,MMP9,TNFα,CRP and IL6in the observation group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).Conclusion:The concurrent radiotherapy and chemotherapy can effectively reduce the levels of serum tumor markers,VEGF and MMP9,and effectively reduce the inflammatory stress response in patients with endometrial carcinoma after operation,has a certain clinical value.
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