抗N-甲基-D-天冬氨酸受体脑炎的研究进展  

Research advances in anti-N-methyl-D-aspartate receptor encephalitis

作　　者：刘婷婷[1,2] 王婷[3] 杨琨[1] LIU Ting-Ting;WANG Ting;YANG Kun(Department of Immunology, School of Basic Medical Sciences;Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China;Department of Neurology,Yan’an Hospital Affiliated to Kunming Medical University, Kunming 650051, China)

机构地区：[1]第四军医大学基础部免疫学教研室,陕西西安710032 [2]第四军医大学西京医院神经内科,陕西西安710032 [3]昆明医科大学附属延安医院神经内科,云南昆明650051

出　　处：《转化医学电子杂志》2017年第10期12-15,共4页E-Journal of Translational Medicine

基　　金：国家自然科学基金面上项目(81171977)

摘　　要：抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎是一类与神经元胞膜抗原抗体相关的自身免疫性脑炎,目前已越来越受到人们的关注.患者常表现出显著的精神症状、癫痫发作、意识障碍及自主神经功能紊乱等.实验室脑脊液及血清抗体检测可辅助临床诊断.临床上通常对患者进行免疫治疗,早确诊,早治疗对患者病情的恢复尤为重要.目前,随着抗NMDAR脑炎发病率的日益增高,该病已成为最常见的自身免疫性脑炎之一.Anti-N-methyl-D-aspartate receptor(NMD AR)encephalitis,which is associated with antibodies against neuronal cell surface antigens has attracted more and more attention recently.Its clinical manifestation are often characterized by significant psychiatric symptoms,seizures,disturbance of consciousness and autonomic nerve dysfunction.Serum and CSF antibody testing can help the diagnosis.In clinic,immunotherapy are often used,and early diagnosis and treatment are particularly important.As the increasing of the incidence,the disease has become one of the most common autoimmune encephalitis.

关 键 词：自身免疫性脑炎 N-甲基-D天冬氨酸受体 抗体 

分 类 号：R742.9[医药卫生—神经病学与精神病学]