冠心病患者体内循环微粒对血管舒张功能的影响研究  

Effect of circulating microparticles on vasodilatation in coronary heart disease

作　　者：李红文[1] 张炜[1] 李喆[1] 王旭兰[2] 王群让 刘新宏[1] 邢坤[1] 常凤军[1] Li Hongwen;Zhang Wei;Li Zhe(Department of Cardiology,Shaanxi People's Hospital,Xi^an 710068)

机构地区：[1]陕西省人民医院心血管内三科,西安710068 [2]咸阳职业技术学院医学院,咸阳712000 [3]陕西中医药大学附属医院心内科,咸阳712000

出　　处：《陕西医学杂志》2017年第11期1513-1515,共3页Shaanxi Medical Journal

基　　金：国家自然科学基金专项基金资助项目(81341112)

摘　　要：目的:研究冠心病患者体内循环微粒(MPs)对血管舒张功能的影响。方法:选取稳定型心绞痛冠心病患者45例(实验组)和健康体检的健康志愿者20例(对照组),分别抽取两组患者的空腹静脉血,采用两步离心法提取MPs;然后用两组MPs孵育离体SD大鼠胸主动脉,并检测分析二者对血管舒张功能的影响及对一氧化氮(NO)含量的影响。结果:与对照组MPs比较,实验组MPs明显抑制了内皮依赖的血管舒张功能和离体血管NO的产生。结论:冠心病患者体内的MPst通过抑制NO的产生损害内皮依赖的血管舒张功能,提示MPs有作为内皮功能受损标志物的潜能。Objective:To study the effect of circulating microparticles(M P s)from patients with coronary heart disease(CH D)on vasodilatation.Methods:Fasting venous blood from healthy volunteer(n=20)and stable angina pectoris patients(n=45)were obtained.Two steps’centrifugation was used to get MPs from CAHD patients(experimental group)and normal volunteers(control group).Then,effect of MPs on vasodilatation,generation of nitric oxide(N O)of isolated thoracic aorta from SD rats were performed.Results:Compared with control group,MPs from experimental group inhibited the endothelial-depentmend vasodilatation,reduced the generation of NO.Conclusion:MPs from CHD patients inhibited vasodilatation by reduction N O,which indicated that MPs maybe a potential marker of endothelial dysfunction.

关 键 词：冠状动脉疾病/病理生理学 循环微粒 内皮细胞 一氧化氮 血管舒张 

分 类 号：R363.2[医药卫生—病理学]