FLT3基因突变在急性早幼粒细胞白血病中的临床意义  

Clinical Significance of FLT3 Gene Mutation in Patients with Acute Promyelocytic Leukemia

作　　者：徐晓燕 XU Xiao-yan(Department of Hematology,Luoyang Central Hospital,Zhengzhou University,Luoyang, Henan, 471000 ,China)

机构地区：[1]郑州大学附属洛阳中心医院血液内科,河南洛阳471000

出　　处：《临床研究》2017年第12期3-4,共2页Clinical Research

摘　　要：（046探讨急性早幼粒细胞白血病发生中FMS样酪氨酸激酶3(FLT3)基因突变的临床意义。方《取36例急性早幼粒细胞白血病患者，对其骨髓标本采用相应方法和技术检测FLT3基因D835位点基因突变和该基因内部串联重复(FLT3-ITD)情况，并分析FLT3-ITD、FLT3-D835基因突变和临床特点、疗效的关系。锫*FLT3-ITD突变型外周血高WBC、骨髓低B、出血BB、疗效DCR者构成比均明显高于FLT3-ITD野生型（P<0.05);FLT3-D835突变型外周血高WBC者构成比远高于FLT3-D835野生型（P<0_05)。砝铪FLT3-ITD基因突变情况与外周血WBC、骨髓、出血分级和临床疗效均存在有一定关联，而FLT3-D835基因突变情况仅与单纯外周血WBC有关，可根据基因突变情况评估此类患者的病情严重程度和有效性。Objective To investigate the clinical significance of FMS like tyrosine kinase3(FLT3)gene mutation in acutepromyelocytic leukemia(AML).Methods36cases of acute promyelocytic leukemia>with the bone marrow specimens fordetection of FLT3gene D835gene mutations and the corresponding Methods And techniques of gene internal tandem duplication(FLT3-ITD),to determine the relationship between FLT3-ITD and FLT3-D835gene mutation and clinical characteristics,curative effect.Results FLT3-ITD mutation in peripheral blood of high WBC?low B,BB,bone marrow hemorrhage curativeeffect of DCR which were significantly higher than that of the wild type FLT3-ITD(P<C〇.05);composition ratio is muchhigher than the wild type FLT3-D835FLT3-D835mutation in peripheral blood of high WBC(P<C〇.05).Conclusion The mutationof FLT3-ITD gene and WBC in peripheral blood,bone marrow,bleeding grading and clinical curative effect are there is acertain correlation,and the mutation of FLT3-D835gene is only related to simple peripheral blood WBC gene mutation,accordingto the assessment of such disease severity and effectiveness.

关 键 词：FMS样酪氨酸激酶3 急性早幼粒细胞白血病 临床效果 临床意义 

分 类 号：R733[医药卫生—肿瘤]