健康中老年人中心视觉敏感度与光相干断层扫描血管成像的双眼对称性  

Interocular symmetry of foveal threshold and optical coherence tomography angiography in healthy middle-aged and elderly subjects

作　　者：刘瑞[1] 李轻宸 LIU Rui;LI Qingchen(Department of Ophthalmology, Tenth People’s Hospital of Tongji University, Shanghai 200072;Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai 200031, China)

机构地区：[1]同济大学附属第十人民医院眼科,上海200072 [2]复旦大学附属眼耳鼻喉科医院眼科,上海200031

出　　处：《Eye Science》2017年第4期199-205,共7页眼科学报（英文版）

摘　　要：目的:观察健康中老年人群中心凹视觉敏感度阈值(foveal threshold,FT)及光相干断层扫描血管成像(optical coherence tomography angiography,OCTA)的双眼对称性。方法:横断面观察性研究。纳入33例66眼,测量并比较眼灌注压(ocular perfusion pressure,OPP),FT,黄斑区3 mm×3 mm范围内中心凹无血管区面积(non-flow area,NFA),浅层视网膜血管密度(superior vessel density,SVD)和深层视网膜血管密度(deep vessel densit y,DVD)的双眼对称性;分析各指标双眼差值、均值及其比值与年龄、性别的相关性。结果:配对样本t检验结果显示除FT(t=-2.118,P=0.042)外,左右眼OPP,NFA,SVD和DVD差异均无统计学意义(P>0.05);Pearson相关性分析和同类相关系数(intra-class correlation coefficient,ICC)检验结果显示5项指标左右眼测量值相关强度由强到弱为OPP>FT>NFA>DVD>SVD;Bland-Altman分析结果提示5项指标双眼间一致性良好。5项指标的双眼对称性不随性别、年龄改变。结论:健康中老年人群FT、黄斑区NFA,SVD及DVD的测量值具有双眼对称性。Objective:To observe the interocular symmetry of foveal threshold(FT)and optical coherence tomography angiography(OCTA)parameters in healthy middle-aged and elderly subjects.Methods:Cross-sectional observational study.Sixty-six eyes from thirty-three subjects were enrolled to compare binocular ocular perfusion pressure(OPP),FT,non-flow area(NFA),superior vessel density(SVD)and deep vessel density(DVD)in a3mm×3mm OCTA scan of macula.The interocular symmetry of all the parameters was analyzed;the correlations of the differences(△),mean value(m)and the ratio of all the parameters with age and gender were analyzed.Results:There was no significant interocular difference revealed by paired-samples t-tests in all the parameters(P>0.05)except FT(t=?2.118,P=0.042),while the rank of Pearson’s correlation index and intraclass correlation coefficient(ICC)from strong to weak was OPP>FT>NFA>DVD>SVD.The interocular symmetry of all the parameters was proved to be good with Bland-Altman plots,and it changed little with the variations of age and gender.Conclusion:Interocular symmetries of FT and OCTA parameters are observed in healthy middle-aged and elderly subjects.

关 键 词：光相干光断层扫描血管成像 中心凹视觉敏感度阈值 双眼对称性 Bland-Altman检验 

分 类 号：R770.4[医药卫生—眼科]