^(11)C多功能正电子放射性药物合成模块简介与故障分析  

Profile and Failure Analysis of ^(11)C-Multifunction Positron Radiopharmaceuticals Synthesis Module

作　　者：刘健[1] 张晓军[1] 李云钢[1] 何玉林[1,2] 张锦明[1] LIU Jian;ZHANG Xiaojun;LI Yungang;HE Yulin;ZHANG Jinming(Department of Nuclear Medicine, The PLA General Hospital, Beijing 100853, China;Department of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical University, Hohhot Inner Mongolia 010050, China)

机构地区：[1]中国人民解放军总医院核医学科,北京100853 [2]内蒙古医科大学附属医院核医学科,内蒙古呼和浩特010050

出　　处：《中国医疗设备》2018年第1期104-107,共4页China Medical Devices

基　　金：军队医疗机构制剂标准提高科研专项(12ZJZ21-1)

摘　　要：本文主要目的为简介国^(11)C多功能正电子放射性药物合成模块并进行故障分析。合成模块主要分成5部分,本文主要描述故障包括碳多功能模块密闭性故障,^(11)C-CH_3I合成部分、^(11)C-Triflate-CH_3在线转换部分、前体反应与产品粗萃取部分等几部分的常见故障。此外,本文还总结了药物合成模块的常见问题及解决方案。对于此设备的预防性维护,可以根据需要更换管线连接以适应不同药物的标记,并且各部分均安装放射性探头,即时了解放射性分布。This paper aims to introduce the domestic11C multifunctional positron radio-pharmaceuticals synthesis module briefly and analyze the instrument failures.The synthesis module could be divided into5parts,and failures described in this paper mainly included failures of carbon multifunction module’s air tightness,common failures of11C-CH3I synthesis module,11C-Triflate-CH3online conversion module,precursor response module and product crude extraction module.In addition,this paper summarized common problem and solution of drug synthesis module.As for preventive maintenance of this device,pipeline connection can be changed according to demand,and radioactive probe should be installed for all modules in order to understand real-time radioactive distribution.

关 键 词：碳多功能模块 化学合成 故障分析 正电子药物 PET/CT 

分 类 号：R730.5[医药卫生—肿瘤] TH774[医药卫生—临床医学]