富含亮氨酸重复序列免疫球蛋白样蛋白1、E-Cadherin和EGFR在胃癌中的表达和临床意义  

Expression and clinical significance of leucine rich repeat immunoglobulin like protein 1,E-Cadherin and EGFR in gastric carcinoma

作　　者：郑俊全[1] 伊索恒 武杰[1] 石东英[2] ZHENG Jun-quan;YI Suo-heng;WU Jie(Department of Neurosurgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot Inner Mongolia 010050, China)

机构地区：[1]内蒙古医科大学附属医院急诊外科,内蒙古呼和浩特010050 [2]内蒙古医科大学附属医院肾内科,内蒙古呼和浩特010050

出　　处：《临床和实验医学杂志》2017年第23期2329-2332,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨富含亮氨酸重复序列免疫球蛋白样蛋白1(LRIG1)、上皮钙黏蛋白(E-Cadherin)和表皮生长因子受体(EGFR)在胃癌中的表达和及其与临床病理特征的相关性。方法选取50例胃癌患者作为研究对象,并选取正常胃黏膜组织50例作为对照。用免疫组化方法检测两组患者卵巢组织中的LRIG1、E-Cadherin和EGFR的表达,分析LRIG1、E-Cadherin和EGFR的阳性表达率在胃癌患者不同临床病理特征中的差异。采用spearson秩相关分析LRIG1,E-Cadherin和EGFR的阳性表达率的相关性。结果胃癌组的LRIG1、E-Cadherin的阳性表达率显著低于正常胃黏膜组,胃癌组的EGFR的阳性表达率显著高于正常胃黏膜组。胃癌中LRIG1、E-Cadherin和EGFR阳性表达率与临床分期、病理分级和淋巴结转移有关(P<0.05),而与年龄、组织学类型无关(P>0.05)。LRIG1、E-Cadherin和EGFR在胃癌患者中的阳性表达率具有相关性,共同调控参与胃癌的发生和发展。结论 LRIG1、E-Cadherin在胃癌中低表达和EGFR在胃癌中高表达,与胃癌的进展和转移相关。ObjectiveTo study the expression and clinical significance of leucine rich repeat immunoglobulin like protein1,E-Cadherin and epidermal growth factor receptor(EGFR)in gastric cancer.MethodsA total of50patients with gastric cancer were reviewed,and50cases of normal gastric mucosa tissues and benign ovarian epithelial tumor were selected as control.The expressions of LRIG1,E-Cadherin and EGFR were evaluated with immunohistochemistry in the gastric mucosa tissue of two groups of patients.The positive expression rate of LRIG1,E-Cadherin and EGFR and the relationship between their expressions and clinical pathological parameters in patients with gastric cancer with different clinical pathological characteristics were analyzed.The correlation of their expressions in gastric cancer were analyzed as well.ResultsThe positive rates of LRIG1and E-Cadherin in gastric cancer group were significantly lower than those in normal gastric mucosa group.The positive rate of EGFR in gastric cancer group was significantly higher than that in normal gastric mucosa group.The positive expression rates of LRIG1,E-Cadherin and EGFR were closely related to the pathological grade,TNM stage and lymphatic metastasis,but were not related to the age,sex and lymph node metastasis.The positive rates of LRIG1,E-Cadherin and EGFR in gastric cancer patients were related to each other,which could regulate and participate in the occurrence and development of gastric cancer.ConclusionLow expression of LRIG1and E-Cadherin in gastric carcinoma and high expression of EGFR in gastric carcinoma are related to the progression and metastasis of gastric cancer.

关 键 词：胃癌 富含亮氨酸重复序列免疫球蛋白样蛋白1 上皮钙黏蛋白 表皮生长因子受体 

分 类 号：R734.2[医药卫生—肿瘤]