曲美布汀联合阿普唑仑治疗对腹泻型IBS患者胃肠激素的影响  

Effect of trimebutine combined with alprazolam on gastrointestinal hormones in the treatment of diarrhea-type IBS patients

作　　者：杨永利[1] 宋春秋[1] 李红霞[1] 黄晓峰 周红梅[1] YANG Yong-li;SONG Chun-qiu;LI Hong-xia;HUANG Xiao-feng;ZHOU Hong-mei(the Seventh People's Hospital in Hebei Province, Baoding City, Hebei Province, 073000, China)

机构地区：[1]河北省第七人民医院,河北保定073000

出　　处：《海南医学院学报》2017年第19期2642-2644,共3页Journal of Hainan Medical University

基　　金：河北省保定市科学技术研究与发展指导计划项目;编号:16ZF094~~

摘　　要：目的:探讨曲美布汀联合阿普唑仑对腹泻型肠易激综合征(IBS-D)患者胃肠激素及生活质量的影响。方法:选取IBS-D患者117例,随机分为对照组(n=58)和治疗组(n=59)。对照组给予曲美布汀治疗,治疗组给予曲美布汀联合阿普唑仑治疗,2组均连续治疗4周。检测并比较治疗前后2组患者胃肠激素和脑肠肽水平变化;采用SF-36统计并分析治疗前后2组生活质量。结果:治疗后2组MOT、GAS、SP、5-HT水平均显著下降(P<0.05或P<0.01),VIP、SS、CCK、CGRP水平和各维度SF-36评分均显著升高(P<0.05或P<0.01),且组间差异显著(P<0.05或P<0.01)。结论:曲美布汀联合阿普唑仑可显著改善IBS-D患者胃肠激素及脑肠肽水平,提高其生活质量,疗效显著。Objective:To investigate the effect of trimebutine combined with alprazolam on gastrointestinal hormones and quality of life in the treatment of diarrhea-type IBS patients.Methods:117cases of IBS-D were randomly divided into control group(n=58)and treatment group(n=59).The control group was treated with trimebutine,the treatment group was treated with trimebutine combined with sibutramine,2groups were consecutively treated for4weeks.Detected and compared the levels changes of gastrointestinal hormones and ghrelin before and after treatment in2groups o;Statisticsed and analysised the SF-36quality of life scores of2groups before and after treatment.Results:After treatment,the levels of MOT,GAS,SP,5-HT of2groups decreased significantly(P<0.05or P<0.01),the levels of VIP,SS,CCK,CGRP and SF-36scores increased significantly(P<0.05or P<0.01),and the difference between2groups was significant(P<0.05or P<0.01).Conclusion:Trimebutine combined with alprazolam can significantly improve the gastrointestinal hormone level of IBS-D patients and the quality of life,be with significant curative effect.

关 键 词：曲美布汀 阿普唑仑 IBS-D 胃肠激素 生活质量 

分 类 号：R574.4[医药卫生—消化系统]