急性脑梗死患者血清神经束蛋白155抗体的表达及临床意义  

Expression and clinical significance of neurofascin-155 antibodies in patients with acute ischemic stroke

作　　者：金晔 陈欣雅 王玉琴[2] 季秋虹[2] JIN Ye;CHEN Xinya;WANG Yuqin;JI Qiuhong(Medical School of Nantong University,Nantong226001;Department of Neurology,the Affiliated Hospital of Nantong University)

机构地区：[1]南通大学医学院,南通226001 [2]南通大学附属医院神经内科

出　　处：《南通大学学报（医学版）》2017年第5期447-449,共3页Journal of Nantong University(Medical sciences)

基　　金：国家自然科学基金资助项目(81201016);江苏省"六大人才高峰"资助项目(2017-WSN-094);南通市民生示范推广项目(MS32015026);南通大学研究生科技创新计划项目(YKC16099)

摘　　要：目的:探讨急性脑梗死(acute ischemic stroke,AIS)患者血清中神经束蛋白(neurofascin,NF)155抗体表达水平的变化及临床意义。方法:采用酶联免疫吸附法(enzyme-linked immunoabsorbent assay,ELISA)检测AIS患者62例、神经系统变性疾病(neurodegenerative diseases,ND)患者30例和健康对照者60例血清中NF155抗体、高敏C-反应蛋白(high-sensitive C-reactive protein,hs-CRP)的表达水平。结果 :AIS患者血清中NF155抗体水平较ND组及健康对照组显著增高(P<0.01),且其表达量与hs-CRP的含量呈正相关(r=0.639 5,P<0.001)。结论:AIS患者血清中NF155抗体显著升高,且表达量与脑损伤的程度呈正相关,推测其可作为一种评判急性脑缺血损伤程度的标志物。Objective:To investigate changes in neurofascin-155(NF155)antibody expression in serum of patients with acute ischemic stroke(AIS).Methods:ELISA was used to assess NF155antibody levels in62cases of AIS,30patients with neurodegenerative diseases and60healthy volunteers were compared.Enzyme-linked immunoabsorbent assay(ELISA)was also used to detect serum high-sensitivity C-reactive protein(hs-CRP)levels among the subjects.Results:NF155antibody levels in the serum of patients with AIS were significantly higher than in patients with neurodegenerative disease and healthy controls(P<0.01).Conclusions:NF155antibody levels in the serum of patients with AIS were significantly elevated and it could be a useful biomarker for diagnosing AIS and evaluating the degree of damage caused by ischemic injury.

关 键 词：急性脑梗死 酶联免疫吸附法 神经束蛋白155抗体 高敏C-反应蛋白 

分 类 号：R745[医药卫生—神经病学与精神病学]