缺氧缺血性脑病新生儿出生早期电解质水平与预后的关系研究  

Levels of Electrolytes in the Early Days of Neonates with Hypoxic Ischemic Encephalopathy (HIE) Predict the Outcome at Dismiss

作　　者：马兴伟[1] 房晓祎[1] 罗冬玲[1] 陈佩群 林霓阳[1] MA Xing-wei;FANG Xiao-yi;LUO Dong-ling;CHEN Pei-qun;LIN Ni-yang(Pediatric Department of the First Affiliated hospital of Shantou University Medical College, Shantou 515041, China)

机构地区：[1]汕头大学医学院第一附属医院儿科

出　　处：《伤害医学（电子版）》2015年第4期43-46,共4页Injury Medicine(Electronic Edition)

摘　　要：目的探讨出生早期电解质如血钙、血钠、血钾水平及住院时间在预测新生儿缺氧缺血性脑病(HIE)预后中的意义。方法缺氧缺血性脑病新生儿300例，进行临床分度(轻、中、重度)。生后2~4天测血清总钙、血清钠、血清钾浓度，生后12~14天行新生儿行为神经评分(NBNA)。NBNA>35分为预后良好，≤35分为预后不良。出院时计算其住院时间。同期50例生理性黄疸住院患儿为对照组。对血钙总浓度、血钠浓度、血钾浓度、住院时间与NBNA评分之间进行Pearson相关分析。结果HIE新生儿出生早期血清总钙、血钠浓度与NBNA呈正相关，差异具有统计学意义(P<0.01)；不同临床分度间血清总钙、血钠平均值差异具有显著性(P<0.01)。结论血清总钙、血钠水平能较好地预测新生儿缺氧缺血性脑病的预后，且是较为早期、方便、经济的预测方法，值得采用。Objective To explore the prognostic value of serum calcium,sodium and potassium levels of neonates with hypoxic ischemic encephalopathy(HIE),as well as the hospitalization days on the outcome of the patients.Methods300cases of neonates with HIE were included and grouped according to their clinical features.Serum levels of calcium,sodium and potassium were measured on the2nd,3rd and4th day after birth,respectively.Neonatal behavioral neurological assessment(NBNA)was done during days12th^14th after birth to evaluate the outcome of the neonates.The cut off point is NBNA=35.>35indicates a favorable prognosis whereas≤35implies a poor prognosis.Hospitalization days were documented when a HIE neonate was dismissed.50cases of physiologic neonatal jaundice were used as the controls.Person analysis was performed to calculate the coefficients between levels of serum electrolytes and NBNA scores.Results Levels of serum calcium and sodium in neonates with HIE was positively correlated with the NBNA scores of them(P<0.01).The levels of these serum electrolytes were also significantly different among the different groups of HIE neonates(P<0.01).Conclusions Levels of serum calcium and sodium can be used to predict the outcomes of neonates with HIE,with the advantages of economic and easy to be measured.

关 键 词：血清总钙 血钠 血钾 新生儿缺氧缺血性脑病 新生儿行为神经评分 

分 类 号：R742[医药卫生—神经病学与精神病学]