磁共振联合血清GDF3、CYFRA211、CEA检测在乳腺癌诊断中的临床意义  

Diagnostic Value of Magnetic Resonance Imaging Combined with Serum GDF3,CYFRA211 and CEA Detection for Patients with Breast Cancer

作　　者：王海[1] 汤新星[1] 刘红莲[1] 卢萌[1] 刘胜莉 WANG Hai;TANG Xinxing;LIU Honglian;LU Meng;LIU Shengli(Department of Nuclear Medicine, Zhenjiang First People’s Hospital, Zhenjiang, Jiangsu, 212002, China)

机构地区：[1]江苏大学附属人民医院核医学科,江苏镇江212002

出　　处：《肿瘤药学》2017年第6期708-712,共5页Anti-Tumor Pharmacy

摘　　要：目的探讨核磁共振联合血清生长分化因子(GDF3)、细胞白蛋白19片段(CYFRA211)、癌胚抗原(CEA)在乳腺癌诊断中的价值。方法选取63例乳腺病变患者作为研究对象,患者均采用核磁共振(MRI)检测,血清GDF3、CYFRA211、CEA测定采用酶联免疫法,观察患者手术病理诊断结果。以手术病理诊断结果作为参考,对比MRI诊断、血清诊断以及二者联合诊断效能以及受试者工作特征(ROC)曲线下面积(AUC)。结果 MRI检测乳腺癌患者诊断符合率91.18%,灵敏度91.30%,特异度90.91%,误诊率8.33%,漏诊率8.70%。血清GDF3、CYFRA211、CEA诊断符合率85.29%,灵敏度84.78%,特异度86.36%,误诊率15.22%,漏诊率13.64%。联合检测诊断符合率97.06%,灵敏度95.65%,特异度100.00%,漏诊率4.35%。联合诊断符合率、敏感度以及AUC值均高于单独检测,差异有统计学意义(P<0.05),而特异度无显著差异(P>0.05)。结论乳腺癌患者采用MRI联合血清GDF3、CYFRA211、CEA检测的诊断效果较好,对于乳腺癌的临床诊断具有一定的参考价值。Objective To investigate the value of magnetic resonance imaging combined with serum growth differentiation factor(GDF3),cell albumin19fragment(CYFRA211)and carcinoembryonic antigen(CEA)in the diagnosis of breast cancer.Methods63breast lesions were selected as the research object,all patients were examined by nuclear magnetic resonance(MRI),Serum GDF3,CYFRA211and CEA were measured by enzyme linked immunosorbent assay(ELISA),the surgical pathologic results acted as reference,comparison of MRI diagnosis,serological diagnosis,combined diagnostic efficacy and receiver operating characteristic(ROC)area under the curve(AUC)value were compared.Results The diagnostic accuracy rate of MRI in breast cancer patients was91.18%,the sensitivity of91.30%,the specificity of90.91%,the misdiagnosis rate was8.33%,and the missed diagnosis rate was about8.70%.The diagnostic accuracy rate of serum GDF3,CYFRA211and CEA was85.29%,the sensitivity was84.78%,the specificity was86.36%,the misdiagnosis rate was15.22%,and the missed diagnosis rate was13.64%.The diagnostic accuracy rate of combined detection was97.06%,the sensitivity was95.65%,the specificity was100.00%,and the missed diagnosis rate was4.35%.The diagnostic accuracy,sensitivity,and AUC value of the ROC curve were higher than those of each single test,the difference was significant(P<0.05),and there was no significant difference in specificity(P>0.05).Conclusion Breast cancer patients with MRI diagnosis effect is good,and diagnostic effect was significantly improved when combined with serum GDF3,CYFRA211,CEA diagnostic,which has certain value for clinical detection of breast cancer.

关 键 词：核磁共振 乳腺癌 血清生长分化因子 细胞白蛋白19片段 癌胚抗原 

分 类 号：R737.9[医药卫生—肿瘤]