孕激素拮抗药物联合子宫动脉栓塞术在子宫肌瘤患者中的临床疗效分析  

Clinical Effect and Prognosis of Progesterone Antagonist Combined with Uterine Artery Embolization for Treatment of Patients with Uterine Fibroids

作　　者：牛琳达 徐艳芳 王超 王占荣 单淑凤 杨黎[2] 邓春雷[3] NIU Linda;XU Yanfang;WANG Chao;WANG Zhanrong;SHAN Shufeng;YANG Li;DENG Chunlei(Department of Obstetrics and Gynecology, Zhengzhou Big Bridge Hospital, Zhengzhou, Henan, 450053, China;Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450053, China;Hunan Normal University School of Medicine, Changsha, Hunan, 410013, China)

机构地区：[1]郑州大桥医院妇产科,河南郑州450053 [2]郑州大学第二附属医院妇产科,河南郑州450014 [3]湖南师范大学医学院,湖南长沙410013

出　　处：《肿瘤药学》2017年第6期727-730,751,共5页Anti-Tumor Pharmacy

摘　　要：目的探讨孕激素拮抗药物联合子宫动脉栓塞术治疗子宫肌瘤患者的临床效果及对预后的影响。方法选取2015年1月~12月我院收治的子宫肌瘤患者90例,随机分为两组,对照组应用孕激素拮抗药物治疗,研究组给予孕激素拮抗药物联合子宫动脉栓塞术治疗,分析比较两组患者治疗前后血红蛋白、肌瘤体积以及子宫体积等指标及预后情况。结果治疗前两组患者血红蛋白水平无明显差异(P>0.05),治疗后均得到一定改善,且研究组显著优于对照组(P<0.05);治疗前两组患者的肌瘤体积及子宫体积对比无明显差异(P>0.05),治疗后均得到一定改善,且研究组显著优于对照组(P<0.05);两组患者不良反应率比较无显著差异(P>0.05)。结论子宫肌瘤患者应用孕激素拮抗药物联合子宫动脉栓塞术治疗的效果理想,有利于改善患者预后。Objective To investigate the clinical efficacy and prognosis of patients with uterine fibroids treated with progesterone antagonist combined with uterine artery embolization.Methods90patients with uterine leiomyoma were randomly divided into control group and study groupfrom January to December2015in our hospital,45cases for each group.The patients in control group were given progesterone antagonist drug treatment,while the patients in study group were given progesterone antagonist drugs combined with uterine artery embolization.The hemoglobin,uterine fibroid volume,and uterine volume were compared before and after treatment between the two groups.Results The hemoglobin level of patients intwo groups before treatment had no significant difference(P>0.05),theybothwere improved after treatment,the study group was significantly better than that in control group(P<0.05);the myoma volume and uterine volume of patients between the two groups before treatment had no significant difference(P>0.05),they obtainedcertain improvement in study group after treatment which was significantly better than that in the control group(P<0.05);the incidence of adverse reactions had no significant difference between the two groups after treatment(P>0.05).Conclusion The application of progesterone antagonist combined with uterine artery embolization for treatment of patients with uterine fibroids is effective,which is helpful to improve the prognosis of patients.

关 键 词：孕激素拮抗药物 米非司酮 子宫动脉栓塞术 子宫肌瘤 预后 

分 类 号：R737.33[医药卫生—肿瘤]