氟尿嘧啶缓释剂在胃癌手术治疗中的应用及对血清E-CAD、CEA和CA72-4的影响  

Application of Fluorouracil Sustained-release Agent for Treatment of Patients with Gastric Cancer and Its Effect on Serum E-CAD,CEA and CA72-4

作　　者：谢海伟[1] 周国志 王冬冬 曹秀峰[1] 朱斌[1] XIE Haiwei;ZHOU Guozhi;WANG Dongdong;CAO Xiufeng;ZHU Bin(Department of Surgical Oncology,Nanjing First Hospital, Nanjing, Jiangsu, 210006, China;Department of Oncology, Yifu Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, 211100, China;Department of Oncology, Yancheng City No.1 People’s Hospital, Yancheng, Jiangsu, 224000, China)

机构地区：[1]南京医科大学附属南京医院/南京市第一医院肿瘤外科,江苏南京210006 [2]南京医科大学附属逸夫医院肿瘤科,江苏南京211100 [3]盐城市第一人民医院肿瘤科,江苏盐城224000

出　　处：《肿瘤药学》2017年第6期731-734,共4页Anti-Tumor Pharmacy

基　　金：南京医科大学科技发展基金重点项目(2013NJMU082)

摘　　要：目的探讨氟尿嘧啶缓释剂在胃癌手术治疗中的应用效果及对血清E-CAD、CEA和CA72-4水平的影响。方法选择2014年12月~2016年12月我院收治的胃癌患者90例,按随机数字法分为对照组(n=45)和观察组(n=45)。对照组采用胃癌根治切除手术治疗,观察组术后给予5-氟尿嘧啶缓释剂治疗,采用酶联免疫吸附试验测定两组血清E-CAD水平;采用放射免疫试验测定两组血清CEA和CA72-4水平,比较两组患者的临床疗效及血清E-CAD、CEA和CA72-4水平。结果两组术前E-CAD、CEA和CA72-4水平比较,差异无统计学意义(P>0.05);观察组术后E-CAD、CEA和CA72-4水平显著低于对照组(P<0.05);两组患者治疗后18个月生存率比较,差异无统计学意义(P>0.05);观察组治疗后6个月、12个月生存率显著高于对照组(P<0.05);观察组术后并发症发生率为13.33%,对照组为15.56%,差异无统计学意义(P>0.05)。结论胃癌患者在根治切除术基础上给予5-氟尿嘧啶缓释剂治疗效果理想,可降低血清E-CAD、CEA和CA72-4水平,值得临床推广应用。Objective To investigate the effect of fluorouracil sustained-release agent for treatment of patients with gastric cancer and its effect on serum E-CAD,CEA and CA72-4levels.Methods90patients with gastric cancer were randomly divided into control group(n=45)and observation group(n=45)in our hospital from December2014to December2016.The patients in control group were treated with radical resection of gastric cancer,while the patients in observation group were treated with fluorouracil sustained-release agent based on radical resection of gastric cancer.The level of serum E-CAD was measured by enzyme-linked immunosorbent assay(ELISA).The levels of serum CEA and CA72-4were measured by radioimmunoassay,the level of serum E-CAD,CEA and CA72-4were analyzed between the two groups.Results The levels of E-CAD,CEA and CA72-4of patients before treatment in the two groups were not statistically significant(P>0.05).The levels of E-CAD,CEA and CA72-4of patients in the observation group were lower than those in the control group after treatment(P<0.05).There was no significant difference in the survival rate between the two groups(P>0.05).The6-month and12-month survival rate of patients in the observation group was higher than that in the control group(P<0.05).The incidence of postoperative complications was13.33%in observation group and that in the control group was15.56%.There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion The treatment effect of5-fluorouracil sustained-release agent based on radical resection is the best way to reduce the levels of serum E-CAD,CEA and CA72-4,and it is worthy to be popularized.

关 键 词：氟尿嘧啶缓释剂 胃癌手术 E-CAD CEA CA72-4 

分 类 号：R735.2[医药卫生—肿瘤]