Chromatin remodeling factor lymphoid.specific helicase inhibits ferroptosis through lipid metabolic genes in lung cancer progression  

作　　者：Yiqun Jiang Yuchen He Shuang Liu Yongguang Tao 

机构地区：[1]Key Laboratory of Carcinogenesis and Cancer Invasion,Ministry of Education,Xiangya Hospital,Central South University,Changsha 410008,Hunan,P.R.China [2]Key Laboratory of Carcinogenesis,Ministry of Health,Cancer Research Institute,School of Basic Medicine,Central South University,Changsha 410078,Hunan,P.R.China [3]Institute of Medical Sciences,Xiangya Hospital,Central South University,Changsha 410008,Hunan,P.R.China [4]Department of Thoracic Surgery,Second Xiangya Hospital,Central South University,Changsha 410011,Hunan,P.R.China

出　　处：《Chinese Journal of Cancer》2017年第12期669-671,共3页

基　　金：supported by the National Natural Science Foundation of China[81372427 and 81672787(Y.Tao);81271763 and 81672991(S.Liu)];the National Basic Research Program of China[2015CB553903(Y.Tao)]

摘　　要：Ferroptosis, a novel mode of non-apoptotic cell death,involves a metabolic dysfunction that results in the production of iron-dependent reactive oxygen species (ROS),an iron carrier protein (transferrin), intracellular metabolic process, and related regulators (e.g., p53 protein).Previous studies have linked ferroptosis with oncogenic Ras [1], and p53 tumor suppressor positively regulates ferroptosis by transcriptionally inhibiting the expression of the cysteine/glutamate antiporter, which is encoded by the SLC7A11 gene in human [1, 2]. Whether other factors such as epigenetic factors are involved in the process remains less known.Chromatin modifier lymphoid specific helicase (LSH)contributes to the malignant progression of nasopharyngeal carcinoma and glioma [3]. We recently indicated that LSH was shown to co-operate with partners, such as G9a, to drive cancer progression [4, 5].

关 键 词：Ferroptosis  a novel mode of non-apoptotic cell DEATH 

分 类 号：R734.2[医药卫生—肿瘤]