血浆HGF、TNF-α、IL-10的差异与青年脑梗死患者预后的相关性的研究  

Analyze the correlation between the differences of plasma HGF,TNF-α,IL-10 and the prognosis of young patients with cerebral infarction

作　　者：戚游 王玉[1] QI You;WANG Yu(Department of Neurology,The First Affiliated Hospital of Anhui Medical University,Heifei 230022,China)

机构地区：[1]安徽医科大学第一附属医院神经内科,安徽合肥230022 [2]安徽省六安市第二人民医院,安徽六安237008

出　　处：《中风与神经疾病杂志》2017年第12期1100-1103,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨血浆HGF、TNF-α、IL-10的差异与青年脑梗死患者预后的相关性。方法选取我院2015年3月-2016年9月收治的100例青年脑梗死患者作为病例组进行回顾性分析。同时选取我院正常健康体检人员100例作为对照组,观察入院时青年脑梗死患者不同预后组之间及与健康体检组血浆肝细胞生长因子(hepatocyte growth factor,HGF)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、血清白细胞介素10(interleukin 10,IL-10)的浓度差异。并对脑梗死的危险因素如性别、年龄、高血压、吸烟、高血糖、高血脂、高同型半胱氨酸、酗酒、体重指数等因素进行Logistic回归分析。结果病例组入院时血浆HGF、TNF-α的浓度明显高于对照组,而血浆IL-10的浓度明显低于对照组,差异有统计学意义(P<0.05);且预后越差组血浆HGF、TNF-α的浓度越高,IL-10的浓度越低,差异有统计学意义(P<0.05)。通过Logistic回归分析显示高血压、吸烟、高血糖、高血脂、高同型半胱氨酸、酗酒、体重指数是青年脑梗死发病的危险因素(P<0.05),而年龄、性别不是青年脑梗死的危险因素(P>0.05)。结论血浆中HGF、TNF-α浓度与青年脑梗死患者预后呈负相关,而血浆中IL-10浓度则与青年脑梗死患者预后呈正相关。并预测对青年脑梗死患者血浆中HGF、TNF-α、IL-10浓度的监测可能有助于患者预后的预判断。ObjectiveTo explore the correlation between the difference of plasma HGF,TNFα,IL10and the prognosis of young patients with cerebral infarction.MethodsFrom March2015to September2016,100cases of young patients with cerebral infarction in our hospital were selected as case group,and100health examination people as control.The concentrations of hepatocyte growth factor(HGF),tumor necrosis factor alpha(TNFα)and serum interleukin10(IL10)were observed in the two groups,the different prognosis of young patients with cerebral infarction HGF,TNFα,IL10concentration differences are observed.Moreover,the risk factors such as gender,age,hypertension,smoking,hyperglycemia,hyperlipaemia,high homocysteine,alcohol abuse,body mass index etc factors were used to make regression analysis.ResultsThe concentrations of HGF and TNFαin the case group were significantly higher than those in the control group,while the concentrations of IL10inthe case group were significantly lower than those in the control group,differences have statistical significance(P<0.05);moreover,the higher concentrations of HGF and TNFαof patients with the worse prognosis group,the lower concentrations of IL10will be.Differences have statistical significance(P<0.05).Logistic regression analysis showed that hypertension,smoking,hyperglycemia,hyperlipaemia,high homocysteine,alcohol abuse,body mass index were the risk factors for Youth Cerebral Infarction(P<0.05).Moreover,gender and age are not risk factors of young patients with cerebral infarction(P>0.05).ConclusionThe concentrations of HGF,TNFαshow negative correlation with prognosis of young patients with cerebral infarction,but the concentrations of IL10show positive correlation with prognosis of young patients with cerebral infarction.Moreover,the concentration detection of HGF,TNFα,IL10probably contributes to predicting the prognosis young patients'prognosis with cerebral infarction.

关 键 词：青年脑梗死 肝细胞生长因子 肿瘤坏死因子-Α 白细胞介素-10 预后 相关性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]