紫杉醇白蛋白纳米粒的研究现状与进展  

Research Status and Progress of Paclitaxel Albumin Nanoparticles

作　　者：陈东晓 张娟梅[1] 李建业 徐天宏 董亚琴 蒲晓辉[1,2] CHEN Dongxiao;ZHANG Juanmei;LI Jianye;XU Tianhong;DONG Yaqin;PU Xiaohui(Pharmaceutical school of Henan University,Kaifeng 475004,China;Nanjing Lacksen biological medicine technology Co.Ltd,Nanjing 211100,China)

机构地区：[1]河南大学药学院,河南开封475004 [2]南京拉克森生物医药科技有限公司,南京211100

出　　处：《河南大学学报（医学版）》2017年第4期296-300,共5页Journal of Henan University:Medical Science

基　　金：江苏省科技型企业技术创新资金项目(BC2014039)

摘　　要：[目的]综述紫杉醇白蛋白纳米药物传递系统的研究现状与进展。[方法]通过查阅多篇相关文献与专利,对现有紫杉醇白蛋白纳米药物传递系统的制备工艺、作用机制、表面修饰以及临床应用等进行了概括。[结果]紫杉醇白蛋白纳米粒不仅能够显著提高紫杉醇的血药浓度,而且在体内的停留时间明显延长,治疗效果明显增强。同时,白蛋白纳米粒的增溶效果有效地避免了表面活性剂聚氧乙烯蓖麻油以及吐温80等带来的毒副作用。[结论]紫杉醇白蛋白纳米粒用于癌症的治疗有着重要的临床意义以及发展前景。〔Objective〕Summarizing the status and progress of paclitaxel albumin nanoparticles drug delivery system.〔Methods〕Through referring to a number of related literatures and patents,the preparation technology,anti tumor mechanism,surface modification and clinical application of the paclitaxel albumin nanoparticles drug delivery system were summarized.〔Results〕Paclitaxel albumin nanoparticles can not only significantly increase the plasma concentration of paclitaxel,but also prolonged residence time in the body,the treatment effect was significantly enhanced.At the same time,the solubilization effect of albumin nanoparticles can effectively avoid the side effects of surfactants such as polyoxyethylene castor oil and Tween80.〔Conclusion〕The application of paclitaxel albumin nanoparticles for the treatment of cancer has important clinical significance and development prospects.

关 键 词：紫杉醇白蛋白纳米粒 制备工艺 抗肿瘤机制 表面修饰 临床应用 

分 类 号：R965[医药卫生—药理学]