肝纤维化血清学诊断标记物  

A challenge of serological diagnosis in liver fibrosis

作　　者：刘立新[1,2] 吕婷婷[3,4] Liu Lixin;Lyu Tingting(Experimental Center of Science and Research;Department of Gastroenterology,First Hospital of Shanxi Medical University,Taiyuan 030001,China;Shanxi Medical University(Capital Medical University Doctoral Student),Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院科研实验中心,太原030001 [2]山西医科大学第一医院消化科,太原030001 [3]山西医科大学,太原030001 [4]首都医科大学

出　　处：《中华消化病与影像杂志（电子版）》2018年第1期1-6,共6页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

基　　金：国家自然科学基金(81670559);山西省重点研发计划项目(国际合作)(201603D421023)

摘　　要：肝纤维化是各种慢性肝病进展至肝硬化的必经阶段,其临床表现不典型,可进一步发展为肝癌,严重威胁患者生命健康。早期准确评估肝纤维化患者病情对疾病预后具有重要意义,血清学指标因其无创、操作方便、重复性好等优势一直是肝纤维化无创诊断的研究热点。本文简要介绍了传统血清学指标在肝纤维化辅助诊断中的应用,同时评述了指标转化生长因子β1、血清多花紫藤凝集素阳性巨噬细胞结合蛋白及YKL-40的临床应用价值及优缺点。此外,在本课题组长期研究的基础上建议将胰岛素样生长因子结合蛋白相关蛋白1作为进展期肝纤维化及肝硬化的实验室诊断指标。Liver fibrosis is an inevitable process of chronic liver diseases with different causes which may develop to liver cirrhosis.Its clinical manifestations are atypical and can induce liver cancer,which seriously threatens the health of patients.Therefore it is of great significance for patients to assess liver fibrosis accurately and timely.Owing to its advantage of noninvasive,convenient operation and good repeatability,serological indexes have been a research focus in the noninvasive diagnosis of liver fibrosis.This paper briefly introduces the application of conventional serological indexes and reviews the clinical application value,advantages and disadvantages of the index transformation growth factorβ1,Wisteria floribunda agglutinin positive human Mac2binding protein and YKL40.In this paper,we advice the possibility that serum insulin like growth factor binding protein related protein1measurement can be used as a laboratory diagnostic index of progressive liver fibrosis and liver cirrhosis,according to our longtime researches.

关 键 词：肝纤维化 血清学标记物 胰岛素样生长因子结合蛋白相关蛋白1 转化生长因子Β1 诊断 

分 类 号：R575.2[医药卫生—消化系统]