Ghrelin/GHS-R激动剂和MTL/MTL-R激动剂与胃肠动力关系的研究进展  

Advances in Study on Relationship Between Ghrelin/GHS-R Agonist,MTL/MTL-R Agonist and Gastrointestinal Motility

作　　者：李冬永[1] 许青文[1] 徐鹏远[1] LI Dongyong;XU Qingwen;XU Pengyuan(Department of Gastrointestinal Surgery, the Second Affiliated Hospital of Kunming Medical University, Kunming (650000))

机构地区：[1]昆明医科大学第二附属医院胃肠外科,650000

出　　处：《胃肠病学》2017年第12期764-766,共3页Chinese Journal of Gastroenterology

摘　　要：Ghrelin和胃动素(MTL)主要由消化道分泌,有促进胃肠道运动的作用。胃肠动力疾病(DGIM)是主要由神经支配调节障碍导致的胃肠动力或感觉性疾病,以恶心、呕吐、腹痛、腹胀为主要症状。越来越多研究表明,ghrelin、MTL及其受体激动剂与DGIM发生关系密切。本文就ghrelin/GHS-R激动剂和MTL/MTL-R激动剂与DGIM关系的研究进展作一综述。Ghrelin and motilin(MTL)are mainly secreted by digestive tract,and they both can promote gastrointestinal motility.Disorder of gastrointestinal motility(DGIM)is a gastrointestinal motility or sensory disease mainly caused by neuroregulatory disorder,its main symptoms are nausea,vomiting,abdominal pain and abdominal distension.More and more studies have indicated that ghrelin,MTL and their receptor agonists are closely related to DGIM.This article reviewed the advances in studies on relationship between ghrelin/GHS-R agonist,MTL/MTL-R agonist and DGIM.

关 键 词：胃促生长素 受体 胃促生长素 促胃动素 受体 促胃动素 胃肠动力疾病 

分 类 号：R57[医药卫生—消化系统]