沙利度胺对洛哌丁胺治疗失败的化疗相关性腹泻的疗效观察  

Clinical curative effects of thalidomide on chemotherapy-induced diarrhea refractory to loperamide

作　　者：高明珠[1] 轩菡[1] 王进有[1] GAO Minzhu;XUAN Han;WANG Jinyou(The Second Affiliated Hospital of Anhui Medical University,Hefei 230601,China)

机构地区：[1]安徽医科大学第二附属医院,安徽合肥230601

出　　处：《临床医药实践》2018年第2期83-85,共3页Proceeding of Clinical Medicine

摘　　要：目的:探讨沙利度胺对洛哌丁胺治疗失败的化疗相关性腹泻(CID)的临床疗效和安全性。方法:对35例洛哌丁胺治疗失败的3级CID肿瘤患者采用沙利度胺片进行治疗,口服100 mg,每日2次,每隔24 h观察一次疗效。结果:所有患者均行客观疗效及安全性评价,总有效率为77.1%(27/35),平均有效缓解时间为3.1 d;8例(22.9%)评价为无效。9例(25.7%)患者出现乏力、困倦,3例(8.6%)患者出现恶心,2例(5.7%)患者出现皮疹,均为轻度。结论:采用沙利度胺治疗洛哌丁胺无效的CID是一种安全、有效的方法。Objective:To discuss the clinical curative effects and safety of Thalidomide in the management of chemothera-py-induced diarrhea(CID)refractory to Loperamide.Methods:All35patients with grade3CID tumors who failed loperadine treatment was treated by thalidomide tablets,oral,100mg,twice a day,to observe the effect every24h.Results:All patients re-ceived the evaluation of objective curative effects and safety.The total effective rate was77.1%(27/35)and the average effec-tive release time was3.1d.The effects in8cases(8.6%)were evaluated as invalid.9cases(25.7%)experienced mild drowsiness,fatigue.Mild nausea occurred in3cases(8.6%),and2cases(5.7%)appeared mild rash.Conclusion:Thalido-mide treatment of loperamide ineffective CID is a safe and effective method.

关 键 词：沙利度胺 化疗相关性腹泻 洛哌丁胺治疗失败 

分 类 号：R730.5[医药卫生—肿瘤]