微波消融同步联合肝动脉化疗栓塞治疗大肝癌和巨块型肝癌的安全性和有效性  

Safety and efficacy of microwave ablation combined with transcatheter arterial chemoembolization for large hepatocellular carcinoma and bulky hepatocellular carcinoma

作　　者：刘金明[1] LIU Jinming(Nanchang Ninth Hospital,Nanchang 330002,China)

机构地区：[1]南昌市第九医院,江西南昌330002

出　　处：《临床医药实践》2018年第3期177-179,共3页Proceeding of Clinical Medicine

摘　　要：目的:探究微波消融同步联合肝动脉化疗栓塞治疗大肝癌(直径>5 cm)和巨块型肝癌(直径>10 cm)的安全性和有效性。方法:选择2014年2月—2015年2月大肝癌和巨块型肝癌患者68例,随机分成对照组和观察组,每组34例。对照组应用肝动脉化疗栓塞治疗,观察组采用微波消融同步联合肝动脉化疗栓塞治疗,比较两组的临床疗效和手术并发症发生情况。结果:观察组治疗总有效率为91.2%,明显高于对照组(82.4%),差异有统计学意义(P<0.05)。随访1年后,观察组与对照组的生存率分别为47.0%与17.6%,两组比较差异有统计学意义(P<0.05)。观察组并发症发生率为14.7%,对照组为17.6%,两组比较差异无统计学意义(P>0.05)。结论:采用微波消融同步联合肝动脉化疗栓塞治疗大肝癌(直径>5 cm)和巨块型肝癌(直径>10 cm)疗效好,安全性高。Objective:To investigate the safety and efficacy of microwave ablation combined with transcatheter arterial chemoembolization in the treatment of large hepatocellular carcinoma(diameter5cm)and bulky hepatocellular carcinoma(diameter>10cm).Methods:All68cases of large hepatocellular carcinoma(HCC)and massive hepatocellular carcinoma(HCC)from February2014to February2015were randomly divided into control group and observation group(n=34).The control group was treated with transcatheter arterial chemoembolization,while the observation group was treated with microwave ablation combined with transcatheter arterial chemoembolization.The clinical efficacy and complications of the two groups were compared.Results:The total effective rate of the observation group was91.2%,which was significantly higher than that of the control group(82.4%),and the difference was statistically significant(P<0.05).After1years of follow-up,the survival rate of the observation group and the control group were47.0%and17.6%,and the difference between the two groups was statistically significant(P<0.05).The complication rate of the observation group was14.7%,and the complication rate of the control group was17.6%.There was no significant difference between the two groups(P>0.05).Conclusion:Microwave ablation combined with transcatheter arterial chemoembolization in the treatment of large hepatocellular carcinoma(diameter of5cm)and massive hepatocellular carcinoma(diameter>10cm)has good clinical efficacy and high safety,which can be widely used in clinical practice.

关 键 词：微波消融 肝动脉化疗栓塞 大肝癌 巨块型肝癌 

分 类 号：R735.7[医药卫生—肿瘤]