儿童吉兰-巴雷综合征恢复独立行走能力的短期预后因素分析  

Analyses of the short-term prognostic factors for recovery of independent walking in Guillain Barre syndrome in children

作　　者：孙瑞迪[1] 王晓璐[1] 梁菊芳 罗小青 崔琳[1] 李承[1] 刘智胜[2] 陈娟娟 江军[1] SUN Ruidi;WANG Xiaolu;LIANG Jufang;LUO Xiaoqing;CUI Ling;LI Cheng;LIU Zhisheng;CHEN Juanjuan;JIANG Jun(Department of Electrophysiology,Wuhan Children Hospital,Wuhan 421000, Hubei,China;Department of neurology, WuHan children hospital,Wuhan 421000,Hubei,China;Department of pediatric ,ShiYan tai he hospital,Shiyan 44200,Hubei,China)

机构地区：[1]武汉市妇女儿童医疗保健中心神经电生理室,湖北武汉430000 [2]华中科技大学同济医学院附属武汉儿童医院神经内科,湖北武汉430000 [3]十堰市太和医院儿科,湖北十堰442000

出　　处：《临床儿科杂志》2018年第3期178-181,共4页Journal of Clinical Pediatrics

基　　金：武汉市科技创新平台-儿童神经疾病临床医学研究中心资助项目(No.2014-160);院内课题支持项目(No.2017FE002)

摘　　要：目的探讨儿童吉兰-巴雷综合征(GBS)的短期预后因素。方法纳入125例GBS患儿,根据在出院后第2个月和第6个月是否可以独立行走进行分组,并比较分析其临床资料。结果 125例患儿中男74例、女51例,平均年龄(84.49±25.32)月,6岁以下儿童41例。102例患儿有前驱感染病史。颅神经受累32例,自主神经受累35例。需要辅助呼吸12例。出院后第2和第6个月,不能独立行走患儿的功能评分>3分、颅神经受累、神经电生理为失神经电位型的比例均高于能独立行走的患儿,差异有统计学意义(P<0.05)。结论影响患儿短期预后的因素为神经电生理为失神经电位型,颅神经受累及功能评分>3。应早期识别不同的患儿,并进行针对性康复训练,改善预后。Objective To explore the prognostic factors in Guillain Barre syndrome(GBS)in children.Methods A total of125children with GBS were included and grouped according to their independent walking at two and six months after discharge,and their clinical data were analyzed.Results In125children(74males,51females)the average age was84.49±25.32months,and41were under6years old.102children had a history of prodromal infections.32children had cranial nerve involvement and35had autonomic nerve involvement.12children need assisted respiration.At2and6months after discharge,when compared with children who could walk independently,the rates of functional score>3,cranial nerve involvement,and neuroelectrophysiology as denervation potential were higher in children who could not walk independently,and the differences were statistically significant(P all<0.05).Conclusions The factors that affect the short-term prognosis are denervation potential in neuroelectrophysiology,cranial nerve involvement,and functional score>3.Early identification of uniqueness in patients and subsequent development of targeted rehabilitation training should be carried out to improve the prognosis.

关 键 词：吉兰-巴雷综合征 独立步行能力 短期预后 儿童 

分 类 号：R745.43[医药卫生—神经病学与精神病学]