急性脑血管疾病患者并发心血管疾病与脂蛋白磷脂酶A2水平的关系探讨  

Exploration of the relationship between the level of lipoprotein phospholipase A2 and cardiovascular disease in patients with acute cerebrovascular disease

作　　者：李裕民 洪柳[1] 郑国成 孙巍[1] 谢家海 甄宏岳 LI Yumin;HONG Liu;ZHENG Guocheng;SUN Wei;XIE Jiahai;ZHEN Hongyue(Internal Medicine-Neurology,Nongken Central Hospital of Guangdong Province,524000, China)

机构地区：[1]广东省农垦中心医院内五(神经内科),广东湛江524000

出　　处：《中国医药科学》2018年第4期165-167,175,共4页China Medicine And Pharmacy

基　　金：广东省湛江市科技攻关计划项目(2016B01165)

摘　　要：目的探究急性脑血管疾病患者并发心血管疾病与脂蛋白磷脂酶A2水平的关系。方法回顾性分析我院自2016年1月~2017年5月收治的急性脑血管疾病患者的临床资料,按是否并发心血管疾病暴露分组,依次为观察组(发生心血管疾病)与对照组(未发生心血管疾病),每组45例,对比两组一般临床资料、实验室相关指标水平的差异,将有差异选项行Logistic回归分析,并采用Pearson相关性分析,明确Lp-PLA2与急性脑血管疾病患者发生心血管疾病的危险因素的相关性。结果观察组患者载脂蛋白A、脂蛋白磷脂酶A2(Lp-PLA2)、纤维蛋白原(Fib)及神经功能缺损评分(NIHSS)等指标水平显著高于对照组;以是否并发心血管疾病为因变量,经Logistic回归分析,载脂蛋白B、Lp-PLA2、Fib及NIHSS评分均为急性脑血管疾病患者发生心血管疾病的危险因素,以Lp-PLA2危险值最高;且经Pearson相关性分析,载脂蛋白B、Fib、NIHSS评分与存在显著正相关(r=0.429、0.411、0.536),均P<0.05。结论 Lp-PLA2表达与载脂蛋白B、Fib、NIHSS评分等水平存高度正相关,且同为急性脑血管疾病患者并发心血管疾病的危险因素,或可成为预测急性脑血管疾病患者并发心血管疾病的风险的敏感指标。Objective To explore the relationship between the level of lipoprotein phospholipase A2and cardiovascular disease in patients with acute cerebrovascular disease.Methods The clinical data of patients with acute cerebrovascular diseases admitted in our hospital from January2016to May2017were retrospectively analyzed.They were divided into the observation group(cardiovascular disease)and the control group(no cardiovascular disease)according to whether it was associated with cardiovascular disease exposure,with45cases in each group.The differences of general clinical data and the level of laboratory related indexes between the two groups were compared.Logistic regression analysis was used to analyze the difference options,and Pearson correlation analysis was used to identify the correlation between Lp-PLA2and risk factors of cardiovascular disease in patients with acute cerebrovascular disease.Results The levels of apolipoprotein A,lipoprotein phospholipase A2(Lp-PLA2),fibrinogen(Fib)and neurological deficit score(NIHSS)in the observation group were significantly higher than those in the control group.Taking the cardiovascular disease as a dependent variable,Logistic regression analysis showed that apolipoprotein B,Lp-PLA2,Fib and NIHSS scores were all risk factors for cardiovascular disease in patients with acute cerebrovascular disease,and the highest risk was Lp-PLA2.And after Pearson correlation analysis,the scores of apolipoprotein B,Fib and NIHSS were positively correlated(r=0.429,0.411,0.536),all P<0.05.Conclusion Lp-PLA2expression is highly positively correlated with apolipoprotein B,Fib and NIHSS scores.It is also a risk factor for cardiovascular disease in patients with acute cerebrovascular disease,and can be used as a sensitive index to predict the risk of cardiovascular disease in patients with acute cerebrovascular disease.

关 键 词：急性脑血管疾病 并发心血管疾病 脂蛋白磷脂酶A2 相关性分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学]