抗DNA病毒信号通路cGAS-STING的研究进展  

Research progress of cGAS-STING signaling pathway in anti-DNA virus immunity

作　　者：欧阳婷 刘晓慧[1] 任林柱[1] OUYANG Ting;LIU Xiaohui;REN Linzhu(College of Animal Science,Jilin University,Changchun 130062,China)

机构地区：[1]吉林大学动物科学学院,长春130062

出　　处：《中国比较医学杂志》2018年第3期103-107,共5页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金面上项目(编号:31772747);国家重点研发计划(编号:2017YFD0500103)

摘　　要：病毒感染后,宿主的固有免疫系统快速地识别病毒并作出应答反应,但免疫系统识别和清除病毒的机制尚未完全阐明。研究表明,细胞识别和检测病毒主要通过受体完成,而环鸟苷酸-腺苷酸合成酶(cyclic GMPAMP synthase,cGAS)是一种新发现的DNA识别受体,它将信号传递给下游的干扰素刺激基因(stimulator of interferon genes,STING)蛋白,诱导产生I型干扰素(type I interferon,IFN-I),从而启动细胞抗病毒免疫反应。本文综述了cGAS-STING信号通路的作用机制及抗病毒相关研究,以期为抗病毒药物的研发提供理论依据。Innate immune system rapidly detects and responds to viruses at the early stage of viral infection.However,the mechanisms by which the immune system recognizes and eliminates them have not been fully clarified so far.Studies have shown that receptors are the primary tool for cell recognition and detection of viruses,and cyclic GMP-AMP synthase(cGAS)is one of the newly found DNA recognition receptors.cGAS transmits the signal to the downstream protein called STING(stimulator of interferon genes)and mediates the production of type I interferon(IFN-I),thereby to initiates the antiviral immunity of cells.This review briefly introduces the mechanism of the cGAS-STING signaling pathway,in order to provide a theoretical basis for the research and development of new antiviral drugs.

关 键 词：抗病毒 干扰素刺激基因 环鸟苷酸-腺苷酸合成酶 固有免疫 

分 类 号：R-33[医药卫生]