急性心肌梗死后血管新生相关分子机制的研究进展  

Research progress on molecular mechanisms of angiogenesis after acute myocardial infarction

作　　者：崔加敏 刘婷婷 孙芳玲 郭德玉 王文 石京山 CUI Jiamin;LIU Tingting;SUN Fangling;GUO Deyu;WANG Wen;SHI Jingshan(Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education,Zunyi Medical University,Zunyi 563099,China;Experimental Animal Center,Xuanwu Hospital of Capital Medical University,Beijing 100053)

机构地区：[1]遵义医学院基础药理教育部重点实验室暨特色民族药教育部国际合作联合实验室,贵州遵义563099 [2]首都医科大学宣武医院实验动物室,北京100053

出　　处：《中国比较医学杂志》2018年第3期108-113,共6页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(编号:81573633;81503049;81373994)

摘　　要：血管新生是指机体在正常生长发育过程中或创伤修复与缺血缺氧条件下,在原有血管丛基础上经出芽或其他方式形成新血管的过程。血管新生大致包括五个阶段:血管基底膜降解、内皮细胞增殖、血管芽生、管腔形成、血管网络稳定及成熟。在缺血性心脏病中,急性心肌梗死严重威胁着人类的健康,其病理特点是心肌血管的狭窄和堵塞,导致心肌梗死。因此,促血管新生成为治疗缺血性心脏病的方法之一。多种促血管生成的细胞因子参与到血管新生的过程中,如多肽类生长因子和脂类介质。本文就缺血性心肌梗死后心肌促血管生成因子的表达做一综述。Angiogenesis is a process that new blood vessels generate on the basis of an original vascular plexus via sprouting or other forms during normal growth and development of an organism or under particular conditions such as wound repairing and ischemic hypoxia.In general,angiogenesis includes five stages:degradation of the vascular basement membrane,endothelial cell proliferation,vascular sprouting,lumen formation and vascular network turning stable and mature.Among ischemic heart diseases,acute myocardial infarction seriously threatens human health,its pathological characteristics include myocardial vascular stenosis and blockage,leading to myocardial infarction.Therefore,the promotion of angiogenesis has become one of the therapies for ischemic heart diseases.A variety of pro-angiogenic cytokines are involved in the process of angiogenesis,such as polypeptide growth factors and lipid mediators.In this paper we review the recent progress in research on the expression of pro-angiogenic factors in myocardium after ischemic myocardial infarction.

关 键 词：心肌缺血 血管新生 促血管生成因子 多肽类生长因子 急性心肌梗死 

分 类 号：R-33[医药卫生]