辅助生殖技术对小鼠表型影响的研究进展  

Research progress on the effects of assisted reproductive technology on phenotypes of mice

作　　者：胡永艳[1] 孔申申[1] HU Yongyan;KONG Shenshen(Laboratory Animal Center,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院实验动物中心,北京100034

出　　处：《中国比较医学杂志》2018年第3期114-118,共5页Chinese Journal of Comparative Medicine

摘　　要：通过辅助生殖技术产生的后代同自然受精后代在遗传物质上几乎无差异,但是研究发现两者在某些表型上存在不同程度的差异。本文通过总结辅助生殖技术对小鼠在性别、生长发育、行为学、寿命、器官和组织代谢以及分子表型等的影响,以期对辅助生殖技术在基因修饰小鼠制作、快速繁殖、净化、保种等一系列应用中可能出现的问题提供一定的指导。The offspring generated by assisted reproductive technology(ART)are considered genetically identical with those generated by natural fertilization.However,studies have found that there are differences between them in some phenotypes to varying extents.In this review,we have summarized the effects of ART on the sex ratio,growth and development,behavior,life expectancy,metabolism of organs and tissues,and molecular phenotypes of mice,providing some guidance to the problems that may arise during the application of ART in the production of genetically modified mice,rapid propagation,purification,embryo cryopreservation,and so on.

关 键 词：辅助生殖技术 表型 小鼠 

分 类 号：R-33[医药卫生]