神经炎症和自噬在脑损伤中的作用  

The roles of neuroinflammation and autophagy in brain injury

作　　者：徐雪[1] 张思然 赵建波[1] 王艳芳[1] 张丽慧[1] XU Xue;ZHANG Si-Ran;ZHAO Jian-Bo;WANG Yan-Fang;ZHANG Li-Hui(Department of Pharmacology, Hangzhou Key Laboratory of Medical Neurobiology, School of Medicine, Hangzhou Normal University, Hangzhou 310036;Department of Neurology, Zhejiang Hospital, Hangzhou 310013, China)

机构地区：[1]杭州师范大学医学院药理学教研室,医学神经生物学市级重点实验室,浙江杭州310036 [2]浙江医院神经内科,浙江杭州310013

出　　处：《健康研究》2018年第1期66-69,72,共5页Health Research

基　　金：国家自然科学基金(81671188);浙江省自然科学基金(LY12H31010)

摘　　要：神经炎症反应在脑损伤的发病机制中起重要作用。自噬是降解细胞内机能障碍的蛋白质和损伤的细胞器的关键生物学过程。自噬异常通过影响炎症反应参与中枢疾病的发病过程。本文对炎症和自噬参与脑损伤病理过程的研究进展进行综述,并进一步讨论自噬对炎症反应的调节机制。Neuroinflammation has proved to play an important role in brain injury.Autophagy is a crucial biological process for cells to degrade dysfunctional proteins and damaged organelles.Abnormal autophagy is known to affect inflammatory responses,which in turn contribute to the pathogenesis processes of central disorders.The paper presents a review on the literature of recent studies into the important roles of inflammation and autophagy in the pathological processes of brain injury.The paper also discusses the underlying mechanism by which autophagy regulates inflammatory responses.

关 键 词：炎症反应 自噬 脑损伤 

分 类 号：R741.02[医药卫生—神经病学与精神病学]