TGR5基本性质及其功能研究进展  

Research progress on basic property and novel function of TGR5

作　　者：高雅卿 石亚男 刘巍 Gao Yaqing;Shi Yanan;Liu Wei(The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150000, China)

机构地区：[1]哈尔滨医科大学附属第四医院,哈尔滨15000

出　　处：《新医学》2018年第3期150-154,共5页Journal of New Medicine

基　　金：国家自然科学基金(81270310)

摘　　要：G蛋白偶联胆汁酸受体Gpbar1(TGR5)是G蛋白偶联受体超家族成员。在多种组织如小肠、胃、肝、肺,特别是胎盘和脾脏中可以检测到高水平的TGR5 mRNA。TGR5不仅是胆汁酸受体,也是多种选择性合成激动剂的受体,调节不同信号通路的衍生物,如核因子-κB、AKT和细胞外信号调节激酶。在代谢调节方面TGR5参与能量稳态、胆汁酸平衡以及葡萄糖代谢。最新的研究已经将TGR5的功能扩大到其他方面,包括炎症反应、癌症和肝脏再生。这些新的发现表明TGR5是多种不同疾病的潜在药物作用靶点。该文对TGR5基本性质及其新功能进行了总结。protein-coupled bile acid receptor Gpbar1(TGR5)is a member of the G protein-coupled receptor(GPCR)super-family.High expression levels of TGR5mRNA can be detected in multiple tissues,such as small intestine,stomach,liver,lung,especially the placenta and spleen.TGR5is not only a bile acid receptor,but also a receptor of a variety of selective synthetic agonists that regulates the derivatives of different signaling pathways,such as nuclear factor-κB(NF-κB),AKT and extracellular signal-regulated kinase(ERK[BF])[BFQ].TGR5is involved in energy homeostasis,bile acid balance and glucose metabolism during the process of metabolic regulation.The latest studies have expanded the range of TGR5function to alternative aspects including inflammatory response,cancer and liver regeneration.These novel findings suggest that TGR5is a potential drug target for multiple diseases.This review summarizes the basic property and novel function of TGR5.

关 键 词：G蛋白偶联胆汁酸受体Gpbar1 G蛋白偶联受体 胆汁酸 受体 

分 类 号：R363[医药卫生—病理学]