黄芩汤颗粒剂联合美沙拉嗪治疗溃疡性结肠炎的疗效及对炎症因子的影响  

Effect of Scutellaria Decoction Granules combined with mesalazine in treating ulcerative colitis and its influence on inflammatory factors

作　　者：丁海荣[1] 王丙信[1] 杨云[1] 李霞[1] 王慧纬[1] DING Hairong;WANG Bingxin;YANG Yun;LI Xia;WANG Huiwei(Department of Gastroenterology,251 Hospital of PLA,Zhangjiakou,Hebei 075000,Chin)

机构地区：[1]中国人民解放军第二五一医院消化内科,河北张家口075000

出　　处：《检验医学与临床》2018年第6期806-809,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨黄芩汤颗粒剂联合美沙拉嗪治疗溃疡性结肠炎(UC)的临床疗效及对患者血清炎症因子的影响。方法选择2016年2月至2017年4月该院收治的126例UC患者,按照随机数字表法分为治疗组与对照组,每组63例。治疗组采取黄芩汤颗粒剂联合美沙拉嗪治疗,对照组单用美沙拉嗪治疗,连续治疗2个月后对两组进行疗效评价,于治疗前后比较两组患者的中医证候积分、纤维结肠镜检积分,并于治疗前后抽取患者的外周静脉血,检测血清白细胞介素(IL)-1β、IL-6、IL-10及肿瘤坏死因子(TNF)-α水平。结果经治疗2个月后,治疗组总有效率达96.83%,高于对照组的80.95%(P<0.05)。经治疗后两组腹痛、腹泻、黏液脓血便、里急后重积分与总积分均有显著降低(P<0.01),治疗组各项中医证候积分及总积分降低比对照组更明显(P<0.01)。经治疗2个月后两组纤维结肠镜检积分均有显著下降(P<0.01),治疗组的纤维结肠镜检积分比对照组降低更明显(P<0.01)。治疗后两组血清IL-1β、IL-6、TNF-α水平均有明显降低,IL-10水平显著升高(P<0.01),治疗组以上血清指标比对照组改善更显著(P<0.01)。结论对UC患者采用黄芩汤颗粒剂联合美沙拉嗪治疗后可取得显著疗效,患者机体内炎性反应可得到缓解,有利于促进肠黏膜的恢复。Objective To investigate the clinical effect of Scutellaria Decoction Granules combined with mesalazine in treating ulcerative colitis(UC)and its influence on the serum inflammatory factors levels.Methods One hundred and twenty-six patients with UC treated in this hospital from February 2016 to April 2017 were selected and divided into the treatment group and control group according to the random number table method,63 cases in each group.The treatment group adopted Scutellaria Decoction Granules combined with mesalazine,while the control group used mesalazine treatment alone.After 2-month continuous treatment,the curative effect in the two groups was evaluated.The scores of Chinese medicine symptom and colonoscopic examination before and after treatment were compared between the two groups.The peripheral venous blood was collected before and after treatment for detecting serum interleukin(IL)-1β,IL-6,IL-10 and tumor necrosis factor(TNF)-αlevel.Results The total effective rate after 2-month treatment in the treatment group was 96.83%,which was higher than 80.95%in the control group(P<0.05).After treatment,the scores of abdominal pain,diarrhea,mucus bloody purulent stool and tenesmus,and total score in the two groups were significantly decreased(P<0.01),but the decrease in the treatment group was more significant compared with the control group(P<0.01).The score of fibercolonoscopic score after treatment in the two groups was significantly decreased(P<0.01),but the decrease in the treatment group was more significant compared with the control group(P<0.01).The levels of serum IL-1β,IL-6 and TNF-αafter treatment in the two groups were significantly decreased,while the IL-10 level was increased significantly(P<0.01),but the improvement of above serum indicators in the treatment group was more significant compared with the control group(P<0.01).Conclusion Adopting Scutellaria Decoction Granules combined with mesalazine for treating UC can achieve a significant effect,the body inflammatory reaction can be signific

关 键 词：黄芩汤颗粒剂 美沙拉嗪 溃疡性结肠炎 炎症因子 

分 类 号：R574.1[医药卫生—消化系统]