内镜下注射聚桂醇和美兰混合液在食管静脉曲张硬化治疗术中的应用  

Application of endoscopic injection of lauromacrogol and methylene blue in sclerotherapy of esophageal varices

作　　者：牟海军[1] 徐靖宇[1] 庹必光[1] 高原[1] 杨媛[1] 周小琳 Hai-jun Mou;Jing-yu Xu;Bi-guang Tuo;Yuan Gao;Yuan Yang;Xiao-lin Zhou(Department of Gastroenterology, the Affiliated Hospital of Zunyi Medical College,Zunyi, Guizhou 563003, China)

机构地区：[1]遵义医学院附属医院消化内科,贵州遵义563003

出　　处：《中国内镜杂志》2018年第3期1-5,共5页China Journal of Endoscopy

基　　金：贵州省科技厅;遵义市科技局科学技术联合基金资助项目(No:黔科合LH字[2014]7573号)

摘　　要：目的分析内镜下注射聚桂醇和美兰混合液在食管静脉曲张硬化治疗术中的应用价值。方法收集2014年6月-2016年2月于该院接受内镜下治疗的62例食管静脉曲张患者的临床资料,其中26例接受内镜下注射聚桂醇治疗(A组),36例接受内镜下注射聚桂醇+美兰混合液治疗(B组),比较两组治疗效果、止血成功率、安全性、并发症及随访复发情况。结果 (1)B组治疗总有效率、急诊止血成功率略高于A组,但对比差异无统计学意义(P>0.05);(2)B组食管静脉曲张清除所需治疗次数少于A组,治疗时间短于A组,差异有统计学意义(P<0.05);(3)B组远期再出血率及总出血率均低于A组,差异有统计学意义(P<0.05);(4)B组术后并发症发生率及随访复发率均低于A组,差异有统计学意义(P<0.05)。结论内镜下注射聚桂醇和美兰混合液在食管静脉曲张硬化治疗术中疗效肯定,止血效果好,患者术后并发症发生率低,复发率低。Objective To discuss the application of endoscopic injection of lauromacrogol and methylene blue in sclerotherapy of esophageal varices.Methods The clinical data of62patients with esophageal varices underwent endoscopic treatment from June2014to February2016were collected,including26cases treated by endoscopic injection of lauromacrogol(A group)and36cases treated by endoscopic injection of lauromacrogol and methylene blue(B group).The treatment effects,success rate of hemostasis,safety,complications and follow-up recurrence were compared between the two groups.Results The total effective rate and success rate of emergency hemostasis in B group were slightly higher than those in A group(P>0.05).The times of treatment for eliminating esophageal varices in B group was less than that in A group,and the duration of treatment was shorter than that in A group(P<0.05).The long-term rebleeding rate and total bleeding rate in B group were lower than those in A group(P<0.05).The incidence of postoperative complications and recurrence rate in B group were lower than those in A group(P<0.05).Conclusion Endoscopic injection of lauromacrogol and methylene blue is effective in the treatment of esophageal varices,and the hemostatic effect is good.The incidence of postoperative complications and the recurrence rate are low.

关 键 词：食管静脉曲张 聚桂醇+美兰混合液 硬化剂 内镜 

分 类 号：R571.3[医药卫生—消化系统]