乙型病毒性肝炎患者血清炎症因子及趋化因子表达及意义  

Expression and significance of serum inflammatory cytokines and chemokines in patients with viral hepatitis B

作　　者：赵小丽[1] 高鹏[1] 刘俊华[1] 周凤蕊[1] 王佳乐[1] 李广明[1] ZHAO Xiao-li;GAO Peng;LIU Jun-hua;ZHOU Feng-rui;WANG Jia-le;LI Guang-ming(Five Department of Liver Disease, The Sixth People’s Hospital of Zhengzhou, Zhengzhou 450061, China)

机构地区：[1]郑州市第六人民医院肝病五科,郑州450061

出　　处：《天津医科大学学报》2018年第2期152-155,共4页Journal of Tianjin Medical University

摘　　要：目的:探讨血清炎症因子(IL-6、IL-10和IL-12)及趋化因子(CXCL16和CXCL11)在乙型病毒性肝炎(乙肝)患者体内的变化及意义。方法:选取乙肝患者93例,其中轻度乙肝患者37例,中度乙肝患者30例,重度乙肝患者26例,同时选取40例健康志愿者作为对照组,检测各组炎症因子(IL-6、IL-10和IL-12)、趋化因子(CXCL16和CXCL11)和生化指标(AST、ALT、TC、TG和DBIL)。结果:轻度、中度和重度组CXCL16和CXCL11明显高于对照组(P<0.05);重度组IL-6、IL-10和IL-12明显高于轻度组、中度组和对照组(P<0.05);中度组IL-6、IL-10和IL-12明显高于轻度组和对照组(P<0.05);轻度、中度和重度组AST、ALT和DBIL明显高于对照组(P<0.05),而TC明显低于对照组(P<0.05);重度组HBV DNA明显高于中度和轻度组(P<0.05);中度组HBV DNA明显高于轻度组(P<0.05);IL-6和IL-12与ALT成正相关(r=0.404和0.434,P<0.05),而IL-10与ALT成负相关(r=-0.341,P<0.05);CXCL16与生化指标无相关性(P>0.05);IL-6、IL-12和IL-10与CXCL16、CXCL11无相关性(P>0.05);HBV DNA与ALT、AST、CXCL16呈正相关(r=0.302、0.305和0.413,P<0.05)。结论:乙肝患者IL-6、IL-10、IL-12以及CXCL16和CXCL11表达上调,其中IL-6、IL-10、IL-12和CXCL11可一定程度反映肝功能损害程度。Objective:To investigate the changes and significance of serum inflammatory factors(IL-6,IL-10and IL-12)and chemokines(CXCL16and CXCL11)in patients with hepatitis B.Methods:Ninety-three patients with chronic hepatitis B were selected,among them37mild patients,30moderate patients and26severe patients.40healthy volunteers were selected as control group.The inflammatory factors(IL-6,IL-10and IL-12),chemokines(CXCL16and CXCL11)and biochemical markers(AST,ALT,TC,TG and DBIL)were detected in each group.Results:The CXCL16and CXCL11of mild,moderate and severe patients were significantly higher than those of the control group(P<0.05).The IL-6,IL-10and IL-12in severe patients were significantly higher than those in the mild,moderate group and control group(P<0.05).The levels of IL-6,IL-10and IL-12in moderate group were significantly higher than those in mild group and control group(P<0.05).The levels of AST,ALT and DBIL in mild,moderate and severe patients were significantly higher than those in control group(P<0.05),while TC was significantly lower than that in control group(P<0.05).The HBV DNA in the severe group were significantly higher than those in the mild group and moderate group(P<0.05).The HBV DNA in the moderate group were significantly higher than those in the mild group(P<0.05).IL-6and IL-12were positively correlated with ALT(r=0.404and0.434,P<0.05),while IL-10was negatively correlated with ALT(r=-0.341,P<0.05);CXCL11was positively correlated with AIL(r=0.433,P<0.05),and CXCL16was uncorrelated with biochemical indexes(P>0.05).IL-6,IL-12and IL-10had no correlation with CXCL16and CXCL11(P>0.05).There was a positive correlation between HBV DNA and ALT,AST,CXCL16(r=0.302,0.305and0.413,P<0.05).Conclusion:The expressions of IL-6,IL-10,IL-12,CXCL16and CXCL11in patients with hepatitis B are up-regulated,and IL-6,IL-10,IL-12and CXCL11could reflect the degree of liver function damage to some extent.

关 键 词：炎症因子 趋化因子 乙肝 生化指标 

分 类 号：R575.1[医药卫生—消化系统]