基于“筋脉横解,肠澼为痔”理论研究兔直肠粘膜内脱垂的发生机制  

Research in the Mechanism of the Rabbits' IRP Based on the “Sinews and Channels Flaccid,Changpi and Haemorrhoids” Theory

作　　者：柯敏辉[1] 郑鸣霄[1] 石荣[2] 吴华嵩[3] 魏霖[1] 程佑民[3] 翁英 KE Minhui;ZHENG Mingxiao;SHI Rong;WU Huasong;WEI Lin;CHENG Youmin;WENG Ying(The Second People’s Hospital of Fujian University of TCM,Fuzhou 350003,China;The Fujian Academy of TCM and Pharmacy,Fuzhou 350003,China;The People’s Hospital of Fujian University of TCM,Fuzhou 350004,China)

机构地区：[1]福建中医药大学附属第二人民医院,福建福州350003 [2]福建中医药大学附属人民医院,福建福州350004 [3]福建省中医药研究院,福建福州350003

出　　处：《中国民族民间医药》2018年第3期43-47,共5页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：国家自然基金面上项目(项目编号:81774118);福建省自然基金面上项目(项目编号:2015J01402)

摘　　要：目的:研究兔直肠粘膜内脱垂(Internal Rectal Prolapse,IRP)发展的阶段性特征,旨在推断IRP的发生机制。方法:将156只兔(雄兔、雌兔各78只),按随机数字表随机分为4组,分别为正常组、造模早期组、造模中期组、造模晚期组,分别于不同阶段取兔解剖,进行力学与病理学分析。结果:造模不同时期兔直肠组织的力学指标均存在统计学差异;造模不同阶段兔直肠组织的镜下征象存在差异;在造模不同时期雌兔与雄兔的力学指标与病理特征差异无统计学意义。结论:不同病理学阶段的兔肛门直肠力学特性存在差异,可能是IRP的发生机制之一。Objective In order to infer the mechanism of IRP,research the stage characteristics of the IRP rabbit.Methods There were 156 rabbits(78 males and 78 females).They were randomly divided into four groups according to the random number table,including the group of the normal group,the early stage group,the middle group and the late stage group.At different periods,the rabbits were dissected and analyzed in mechanics and pathology.Results The mechanical indexes of rectal tissue were different in different period.The image of the rectal tissue at different stages was different.The mechanical indicators and pathological features of female rabbits and male rabbits were not different in different period.Conclusion There were significant differences in the mechanical properties of the anorectal of rabbits in different pathological stages.It could be one of the mechanisms of IRP.

关 键 词：筋脉横解 肠澼为痔 直肠粘膜内脱垂 机制 有限元 HE染色 

分 类 号：R-332[医药卫生]