辅酶Q10对大鼠实验性牙周炎的影响作用  

The Effect of Coenzyme Q10 on Experimental Models of Periodontitis in Rats

作　　者：黄捷 李庆华 任晓斌[3] 杨晶津[4] 陈兴 唐丽 唐军 汪显国[4] HUANG Jie;LI Qinghua;REN Xiaobin;YANG Jingjin;CHEN Xing;TANG Li;TANG Jun;WANG Xianguo(Graduate School of Kunming Medical University,Kunming 650500,China;HongyunHonghe Tobacco(Group)Co.,Ltd.,Kunming 650231,China;Technology Center of China Tobacco Yunnan Industrial Co.,Ltd.,Kunming 650231,China;Affiliated Hospital of Kunming Medical University,Kunming 650500,China)

机构地区：[1]昆明医科大学研究生院,云南昆明650500 [2]云南中烟工业有限责任公司技术中心,云南昆明650231 [3]昆明医科大学附属口腔医院,云南昆明650101 [4]红云红河烟草(集团)有限责任公司,云南昆明650231

出　　处：《中国民族民间医药》2018年第5期25-32,36,共9页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：云南省科技厅-昆明医科大学联合专项重点项目(2012FB008);昆明医科大学附属口腔医院横向项目(HYHH2013HX06);国家自然科学基金(81060086)

摘　　要：目的:观察辅酶Q10(Co Q10)对大鼠实验性牙周炎的影响作用。方法:选取雄性SD大鼠168只,随机分为正常组(N)、模型组(P)、替硝唑组(T)、维生素C组(VC)、辅酶Q10低、中、高剂量组(LQ、MQ、HQ)。灌胃给药第2、4、6周,随机抽取8只,采血检测血浆中IL-1β、TNF-α、PGE2、SOD、GSH-Px、MDA水平;测量大鼠牙槽骨附着丧失,并行HE染色、TRAP染色。结果:Co Q10可降低血浆中IL-1β、TNF-α、PGE2水平;增加SOD、GSH-Px活力,减少MDA含量。结论:Co Q10可抑制和缓解大鼠实验性牙周炎。Objective To investigate the effect of coenzyme Q10(CoQ10)on experimental periodontitis in rats.Methods 168 healthy SD rats were randomly divided into normal group(n),model group(P),tinidazole group(T)and vitamin C group(VC),coenzyme Q10 low,medium,high dose group(LQ,MQ,HQ).Intragastric administration for week 2,4,6,8 rats were randomly selected to detect IL-1β、TNF-α、PGE2、SOD、GSH-Px、MDA of their peripheral blood;The ABL value was detected,and the HE staining and TRAP staining were performed.Results CoQ10 could significantly decrease the levels of IL-1β,TNF-α,PGE2;the activity of GSH-Px and SOD increase more,and MDA decrease.Conclusion CoQ10 can inhibit the experimental periodontitis in rats.

关 键 词：辅酶Q10 牙周炎 氧化应激 

分 类 号：R-332[医药卫生]