普萘洛尔与平阳霉素治疗婴儿血管瘤疗效的比较  

Compare the efficacy of propranolol and pingyangmycin on infant hemangioma treatment

作　　者：龚伟[1] 余强[1] 程继文[1] 王怀杰[1] 吴宣林[1] GONG Wei;YU Qiang;CHENG Jiwen;WANG Huaijie;WU Xuanlin(Department of Pediatric Surgery,The Second Affiliated Hospital of Xi′an Jiaotong University,Xi′an,Shaanxi 710004,China)

机构地区：[1]西安交通大学第二附属医院小儿外科,陕西西安710004

出　　处：《安徽医药》2018年第4期743-746,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的比较普萘洛尔与平阳霉素在婴儿血管瘤治疗上的疗效。方法将143例婴儿血管瘤患者分为平阳霉素组和普萘洛尔组,其中,平阳霉素组患者80例,给予局部定期注射平阳霉素治疗血管瘤,普萘洛尔组患者63例,给予规律口服普萘洛尔治疗血管瘤,观察比较两组患者血管瘤治疗效果。结果两组患者在性别分布(χ~2=1.13,P=0.26)、病灶部位分布(χ~2=1.23,P=0.54)以及年龄分布(Z=-0.665,P=0.51)上均差异无统计学意义(P>0.05);平阳霉素组患者有效率88.75%,瘤体缩小超过一半的患者占61.25%,普萘洛尔组患者有效率95.24%,瘤体缩小超过一半的患者占84.13%。两组有效率及瘤体面积缩小超过一半比例的差异有统计学意义(P<0.05)。两组均有不同程度和比例的不良反应发生,程度较轻,经对症处理后均好转。结论普萘洛尔治疗婴儿血管瘤安全有效,不良反应轻,值得作为婴儿血管瘤临床一线治疗来推广。Objective To compare the efficacy of propranolol and Pingyangmycin on infant hemangioma treatment.Methods143cases of infantile hemangioma were selected and randomly divided into two groups:pingyangmycin group(80patients included),who were given locally regular injections of pingyangmycin as a treatment of infantile hemangioma;propranolol group(63patients included),who were given oral propranolol,therapeutic effects were compared between the two groups.Results The distributions of gender(χ2=1.13,P=0.26),lesion(χ2=1.23,P=0.54)and age(Z=-0.665,P=0.51)had no significant difference between the two groups(P>0.05);efficiency in pingyangmycin group was88.75%,and the ratio of reduction that more than half was61.25%,which in propranolol group were95.24%and84.13%,and the differences were statistically significant(P<0.05).Both groups had adverse reactions occur,but all side effects were mild,and they were improved after symptomatic treatment.Conclusions Propranolol is a safe and effective treatment of infant hemangioma,light adverse reactions are controlled,it should be promoted as a first-line treatment of infant hemangioma.

关 键 词：平阳霉素 普萘洛尔 婴儿血管瘤 

分 类 号：R732.2[医药卫生—肿瘤]