一种新铂类化合物的合成方法  

Synthesis of a new compounds of platinum

作　　者：肖毅 XIAO Yi(Wuhan Bio-Raid Biotechnology Co.,Ltd.,Wuhan 430075,China)

机构地区：[1]武汉波睿达物生物科技有限公司,湖北武汉430075

出　　处：《药学研究》2018年第2期122-124,共3页Journal of Pharmaceutical Research

摘　　要：目的本文介绍了一种新的铂类抗癌药物的合成方法,以及此药物对肝癌的体外抑制作用。方法本药物以胆酸作为载体,通过与铂配合,形成有机铂化合物。结果体外试验表明本药物对肝癌细胞株BEL-7402及Hep G2的生长均具有明显的抑制作用。结论胆酸铂的抗癌作用明显高于顺铂。Objective In this paper,a new synthesis methods of platinum anticancer drugs was introduced,as well as the drug in vitro inhibitor^^effect on liver cancer.Methods The drugs used cholic acid as the carrier,and chelated to platinum,for^ned organic compounds of platinum.Results In vitro experiments show-ed that bile acid platinum can inhibit the growth of liver cancer cell line BEL-7402 and HepG2.Conclusion The anticancer effect of cholate platinum was significantly higher than that of cisplatin.

关 键 词：铂类抗癌药物 胆酸 二氨基丙酸 抗癌药物 

分 类 号：R914.5[医药卫生—药物化学]