原发性干燥综合征患者干眼病的临床特征及治疗效果  

Clinical characteristics and therapeutic effect of dry eye disease in patients with primary Sjogren's syndrome

作　　者：岳建中[1] 王晶晶[1] YUE Jian-zhong;WANG Jing-jing(Ophthalmology Department,Hanzhong Central Hospital,Hanzhong 723000,China)

机构地区：[1]汉中市中心医院眼科,陕西汉中723000

出　　处：《临床医学研究与实践》2018年第9期97-98,共2页Clinical Research and Practice

摘　　要：目的探讨原发性干燥综合征患者干眼病的临床特征及治疗效果。方法选取2014年1月至2016年6月在我院就诊的128例原发性干燥综合征患者,按治疗方法分为对照组和观察组,每组64例。对照组给予羟糖甘滴液治疗,观察组在对照组的基础上加用小牛血去蛋白提取物眼用凝胶治疗。比较两组患者的治疗效果及临床特征。结果原发性干燥综合征患者干眼病女性居多,以干燥眼为主要临床表现。治疗后,两组泪膜破裂时间明显延长,且观察组长于对照组(P<0.05);两组泪液分泌浸润滤纸的长度均延长,且观察组明显长于对照组(P<0.05);观察组荧光素角膜活体染色评分下降(P<0.05),且观察组评分低于对照组(P<0.05)。结论原发性干燥综合征患者干眼病主要表现为干燥眼,女性居多,羟糖甘滴眼液联合运用小牛血去蛋白提取物眼用凝胶治疗原发性干眼症患者疗效明显,可预防性应用。Objective To investigate the clinical characteristics and therapeutic effect of dry eye in patients with primary Sjogren's syndrome.Methods One hundred and twenty-eight cases of primary Sjogren's syndrome in our hospital from January 2014 to June 2016 were divided into control group and observation group according to treatment methods,with 64 cases in each group.The control group was treated with hypromellose 2910,dextran 70 and glycerol eye drops,and the observation group was treated with deproteinized calfblood extract eye gel on the basis of the control group.The therapeutic effects and clinical features of the two groups were compared.Results Dry eye is the main clinical manifestation in patients with dry eye disease in primary Sjogren's syndrome.After treatment,the tear break-up time of the two groups significantly prolonged,and that in the observation group was longer than the control group(P<0.05).The tear secretion infiltration filter paper length of the two group prolonged,and that in the observation group was significantly longer than the control group(P<0.05).The corneal fluorescein staining score of the observation group decreased(P<0.05),and that of the observation group was lower than the control group(P<0.05).Conclusion Dry eye is the main manifestation of dry eye in patients with primary Sjogren's syndrome,and most of them are women.The combination of hypromellose 2910,dextran 70 and glycerol eye drops and deproteinized calfblood extract eye gel in the treatment of patients with primary dry eye is effective and can be preventively used.

关 键 词：原发性干燥综合征 干眼病 小牛血去蛋白提取物眼用凝肢 

分 类 号：R777.34[医药卫生—眼科]