Neurokinin 1受体对脊髓后角疼痛传递和调控作用的研究进展  

Research progress on the role of Neurokinin 1R in the spinal cord antihorn involved transmission and regulation of pain

作　　者：王佳 单群群[2] 祁健[2] 

机构地区：[1]济南军区总医院科训科,山东济南250031 [2]济南军区总医院脊髓修复科,山东济南250031

出　　处：《实用医药杂志》2018年第3期276-278,共3页Practical Journal of Medicine & Pharmacy

基　　金：原济南军区总医院院长基金(2016ZX02)

摘　　要：脊髓后角在伤害性刺激传递中起着重要的作用,将初级传入含有的疼痛信息传递到大脑。伤害性疼痛的初级传入主要终止于Ⅰ层和Ⅱ层,其中一些初级传入包含P物质。许多Ⅰ层的投射神经元发出纤维到大脑的不同区域,包括延髓腹外侧区,导水管周围灰质,丘脑。Neurokinin 1受体(NK1R)在脊髓后角的许多神经元表达,这些神经元接受含有P物质的初级传入。80%的Ⅰ层投射神经元表达NK1R阳性。在Ⅲ层和Ⅳ层,同样存在着NK1R阳性神经元,它们不但发出纤维投射到延髓腹外侧区,而且发出纤维调控Ⅰ层的投射神经元。脊髓后角的NK1R阳性神经元既受到局部抑制性神经元的调控,又受到下行调控系统的控制。Spinal cord antihorn plays an important role in the transmission of injurious stimulation,transmitting the primary afferent of pain information to the brain.The primary afferent of injury pain is primarily terminated in theⅠandⅡlayers,some of which contain the substance P.Many projection neurons ofⅠlayers emit fibers to different areas of the brain,including the lateral side of the medullary,the gray matter around the aqueduct,the thalamus.The Neurokinin 1 receptor(NK1R)is expressed in many neurons in the back of the spinal cord,and these neurons accept a primary afferent containing the substance P.The 80%of the projection neurons inⅠ-layer express NK1R.There are also NK1R positive neurons in theⅢandⅣlayers,which not only send the fibers to the lateral side of the medullary,but also emit fibers to control the projection neurons of theⅠlayer.The NK1R positive neurons in the back of the spinal cord are regulated by both local inhibitory neurons and the downward control system.

关 键 词：脊髓后角 伤害性疼痛 NEUROKININ 1(NK1)受体 Γ-氨基丁酸 甘氨酸 下行抑制系统 

分 类 号：R681.5[医药卫生—骨科学]