NEUROKININ

作品数：17被引量：20H指数：2
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相关领域：医药卫生更多>>
相关作者：陈积愫魏尔清张纬萍田炯祁健更多>>
相关机构：兰州大学浙江大学山东省眼科研究所济南军区总医院更多>>
相关期刊：《实用医药杂志》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Pharmacology & Pharmacy》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划济南军区总医院院长基金更多>>
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Neurokinin-2 receptor antagonist SR48968 induced necroptosis of myeloid leukemia cells by calcium overload-driven reactive oxygen species accumulation
《Genes & Diseases》2024年第5期33-35,共3页Zhibin Yan Xiangyu Hong Qihao Lin Leijie Wang Gang Shao Chentao Ge Ruilong Xia Caiyun Fu 
the Zhejiang Provincial Natural Science Foundation of China(No.LD22H310004);the“Pioneer”R&D program of Zhejiang,China(No.2022C03005);the National Natural Science Foundation of China(No.81770176,82204492);the Special Support Plan for Zhejiang Province High-Level Talents(China)(No.2019R52011).
Increasing evidence highlight tachykinin receptors as a prominent player in hematological malignancy.We previously revealed the proto-oncogenic role of neurokinin-1 receptor(NK-1R)in acute myeloid leukemia(AML),1 wher...
关键词：MYELOID ANTAGONIST markedly 
Construction of an intranasal drug delivery system with hypothalamus-targeting nanoparticles
《SusMat》2024年第4期65-76,共12页Qianru Rao Yujie Xu Xiaorong Wang Hang Luo Haoqi Li Jingyuan Xiong Huile Gao Guo Cheng 
National Natural Science Foundation of China,Grant/Award Numbers:82173512,82304135。
Dysfunction of the hypothalamus is associated with endocrine imbalances,growth abnormalities,and reproductive disorders.However,there is a lack of targeted treatment strategies focused on the hypothalamus.In this stud...
关键词：HYPOTHALAMUS intranasal delivery NANOPARTICLES neurokinin receptor 3 
Substance P promotes epidural fibrosis via induction of type 2 macrophages
《Neural Regeneration Research》2023年第10期2252-2259,共8页Feng Hua Hao-Ran Wang Yun-Feng Bai Jin-Peng Sun Wei-Shun Wang Ying Xu Ming-Shun Zhang Jun Liu 
supported by the National Natural Science Foundation of China,Nos.82172486(to JL),82171738(to MSZ),81671563(to MSZ);Jiangsu Provincial Commission of Health and Family Planning,No.JSWST-028(to JL);"Six One"Project of Jiangsu Province,No.LGY2016018(to JL);Jiangsu Provincial Personnel Department"the Great of Six Talented Man Peak"Project,No.WSW-040(to JL)。
In response to spinal surgery,neurons secrete a large amount of substance P into the epidural area.Substance P is involved in macrophage differentiation and fibrotic disease.However,the specific roles and mechanisms o...
关键词：dorsal root ganglion epidural fibrosis LAMINECTOMY MACROPHAGE MITOCHONDRIA neurokinin receptor 1 neutrophil extracellular traps sphingomyelin synthase 2 substance P 
Simulation of the oxidative metabolization pattern of netupitant,an NK1 receptor antagonist,by electrochemistry coupled to mass spectrometry
《Journal of Pharmaceutical Analysis》2021年第5期661-666,共6页Ruxandra Chira Jens Fangmeyer Ioan O.Neaga Valentin Zaharia Uwe Karst Ede Bodoki Radu Oprean 
The authors gratefully acknowledged the financial support for part of this work by the German Research Foundation(DFG,Grant No.:KA 1093/7-2,Bonn,Germany);as well as Iuliu Hațieganu University(Internal Grant No.:5200/19/01.03.2017);a grant of the Romanian Ministry of Education and Research,CCCDI-UEFISCDI(Project No.:PNe-Ⅲ-P2-2.1-PED-2019-5473)within PNCDIⅢ.
Considering the frequent use of netupitant in polytherapy,the elucidation of its oxidative metabolization pattern is of major importance.However,there is a lack of published research on the redox behavior of this nove...
关键词：Netupitant Oxidative metabolism Neurokinin-1 antagonist EC/LC/MS 
Effect of Antiemetic Agents on Hiccups during Chemotherapy in Patients with Lung Cancer
《Pharmacology & Pharmacy》2018年第4期124-133,共10页Shinya Toriumi Kazuharu Nakazawa Masaru Shoji 
Hiccups commonly occur in patients undergoing chemotherapy for lung cancer and may diminish their motivation for treatment. Therefore, it is important to characterize the hiccups and their risk factors. We examined th...
关键词：HICCUPS DEXAMETHASONE Neurokinin-1 Receptor ANTAGONIST ANTIEMETIC AGENTS Lung Cancer 
Neurokinin 1受体对脊髓后角疼痛传递和调控作用的研究进展
《实用医药杂志》2018年第3期276-278,共3页王佳 单群群 祁健 
原济南军区总医院院长基金(2016ZX02)
脊髓后角在伤害性刺激传递中起着重要的作用,将初级传入含有的疼痛信息传递到大脑。伤害性疼痛的初级传入主要终止于Ⅰ层和Ⅱ层,其中一些初级传入包含P物质。许多Ⅰ层的投射神经元发出纤维到大脑的不同区域,包括延髓腹外侧区,导水管周...
关键词：脊髓后角 伤害性疼痛 NEUROKININ 1(NK1)受体 Γ-氨基丁酸 甘氨酸 下行抑制系统 
Extracellular signal-regulated kinase, substance P and neurokinin-1 are involved in the analgesic mechanism of herb-partitioned moxibustion被引量：8
《Neural Regeneration Research》2017年第9期1472-1478,共7页Zhi-yuan Li Yan-ting Yang Jue Hong Dan Zhang Xiao-fei Huang Li-jie Wu Huan-gan Wu Zheng Shi Jie Liu Yi Zhu Xiao-peng Ma 
supported by the National Natural Science Foundation of China,No.81273843,81674073;a grant from the National Key Basic Research Program of China(973 Program);No.2015CB554501;the Project Fund of Shanghai Municipal Commission of Health and Family Planning of China,No.20144Y0153,2017BR047
Herb-partitioned moxibustion can effectively mitigate visceral pain, a major symptom in inflammatory bowel disease, but the analgesic lnechanism is still unclear. Moreover, extracellular signal-regulated kinase, subst...
关键词：nerve regeneration inflammatory bowel disease visceral pain herb-partitioned moxibustion analgesic effect Tianshu （ST25） Qihai （CV6） dorsal root ganglion extracellular signal-regulated kinase substance P neurokinin-I neural regeneration 
Immunohistochemical expression of SP-NK-1R-EGFR pathway and VDR in colonic inflammation and neoplasia被引量：8
《World Journal of Gastroenterology》2015年第6期1749-1758,共10页Raymond A Isidro Myrella L Cruz Angel A Isidro Axel Baez Axel Arroyo William A González-Marqués Carmen González-Keelan Esther A Torres Caroline B Appleyard 
Supported by National Institutes of Health Grants,No.U56 CA126379(to Isidro AA and Appleyard CB)and No.R25-GM082406(to Isidro RA);National Science Foundation:Puerto Rico Louis Stokes Alliance for Minority Participation,NSF Project No.0601843(to Isidro RA);The PSMHS Molecular Biology Core Lab,RCMI Grant No.RR003050/MD007579
AIM:To determine the expression of neurokinin-1receptor(NK-1R),phosphorylated epidermal growth factor receptor(p EGFR),cyclooxygenase-2(Cox-2),and vitamin D receptor(VDR)in normal,inflammatory bowel disease(IBD),and c...
关键词：Colitis Colon cancer DYSPLASIA NEUROKININ VITAMIN 
Therapeutic Potential of 17<i>β</i>Estradiol with Tachykinin Neuropeptide NKB and A<i>β</i>(25 - 35) on Na<sup>+</sup>- K<sup>+</sup>ATPase Activity in Aging Female Rat Brain被引量：1
《Advances in Aging Research》2015年第2期19-27,共9页Rashmi Jha Priyanka Mishra Ranjeet Kumar Abbas Ali Mahdi Shivani Pandey Najma Zaheer Baquer Sudha Mahajan Cowsik 
The Na+ - K+ ATPase is an enzyme responsible for the active transport of Na+ and K+ in most eukaryotic cells. The aim of the present study was to determine the effect of Tachykinin neuropeptide, Neurokinin B (NKB) and...
关键词：Na+ - K+ ATPase AGING NEUROKININ B Amyloid Beta (25 - 35) ESTRADIOL 
Effects of Neurokinin-1 Receptor Inhibition on Anxiety Behavior in Neonatal Rats Selectively Bred for an Infantile Affective Trait
《Pharmacology & Pharmacy》2014年第9期859-864,共6页Amanda L. Schott Betty Zimmerberg 
Interest in understanding the etiology and developing new treatments for anxiety disorders in children and adolescents has led to recent studies of neurotransmitters not traditionally associated with neural pathways f...
关键词：ANXIETY Substance P NEUROKININ Receptor Spantide Ultrasonic VOCALIZATIONS 
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