整合素连接激酶和Toll样受体-2在眼附属器黏膜相关淋巴组织淋巴瘤中的表达及其对预后的影响  

Expression of integrin-linked kinase( ILK) and Tolllike receptor( TLR-2) in ocular adnexal MALT lymphoma and the effects on patients' prognosis

作　　者：李宝华[1] 刘平[1] 王新[1] LI Bao-Hua;LIU Ping;WANG Xin(Zhengzhou People’s Hospital,Zhengzhou 450003,Henan Province,China)

机构地区：[1]郑州人民医院眼科,河南省郑州市450003

出　　处：《眼科新进展》2018年第2期164-167,共4页Recent Advances in Ophthalmology

摘　　要：目的研究整合素连接激酶(integrin linked kinase,ILK)与Toll样受体-2(Toll like receptors-2,TLR-2)在眼附属器黏膜相关淋巴组织(mucosa-associated lymphatic tissue,MALT)淋巴瘤中的表达及其对患者生存状况的影响。方法收集46例(46眼)符合眼附属器MALT淋巴瘤诊断标准的患者病灶组织标本,运用免疫组织化学染色法测定其ILK与TLR-2的蛋白表达情况,分析ILK与TLR-2蛋白与患者临床病理特征的关系;同时探讨ILK与TLR-2蛋白表达情况与患者预后的关系。结果患者瘤组织中的ILK与TLR-2蛋白表达阳性率分别为67.4%(31/46)、71.7%(33/46)。患者瘤组织中ILK、TLR-2蛋白表达阳性率均与性别、年龄、病灶部位均无关(均为P>0.05),均与Ann Arbor临床分期相关(均为P<0.05)。ILK蛋白表达阳性患者的生存期(治疗结束至随访末期的时间)为(21.5±2.7)个月,低于ILK蛋白表达阴性患者的生存期(29.2±2.1)个月(P<0.05);TLR-2蛋白表达阳性患者的生存期为(20.4±1.7)个月,低于TLR-2蛋白表达阴性患者的生存期(27.6±2.3)个月(P<0.05)。结论 ILK、TLR-2与眼附属器MALT淋巴瘤的生物学行为密切相关;联合检测ILK、TLR-2对此类疾病诊断及患者预后具有一定的指导价值。Objective To investigate the expression of integrin-linked kinase(ILK)and Toll-like receptor(TLR-2)in ocular adnexal mucosa-associated lymphoid tissue(MALT)lymphoma and the effects on patients’outcomes.Methods Tissue specimens from 46 patients with MALT lymphoma were collected in this study.The expression of ILK and TLR-2 protein was detected by immunohistochemical methods,and the correlation of ILK and TLR-2 protein expression with clinicopathological features and patients’outcomes was analyzed.Results The positive rates of ILK and TLR-2 protein expression in tumor tissues were 67.4%(31/46)and 71.7%(33/46),respectively,which was related to the clinical stage of AnnArbor(P<0.05),rather than to sex,age and lesion location(all P>0.05).The survival of patients with ILK positive expression was less than that of ones with ILK negative expression[(21.5±2.7)months vs.(29.2±2.1)months](P<0.05);meanwhile,the survival of patients with TLR-2 positive expression was less than that of ones with TLR-2 negative expression[(20.4±1.7)months v.(27.6±2.3)months](P<0.05).Conclusion ILK and TLR-2 are closely related to biological behavior of ocular adnexal MALT lymphoma,and combination detection of ILK and TLR-2 has a certain guiding value for diagnosis and prognosis.

关 键 词：整合素连接激酶 Toll样受体-2 眼附属器 黏膜相关淋巴组淋巴瘤 

分 类 号：R777[医药卫生—眼科]