准分子激光上皮下角膜磨镶术弃瓣中乙醇残留含量检测分析  

Quantitative analysis of residual ethanol content in corneal epithelium flaps in LASEK

作　　者：吴震 吴化宇 蔡娟娟 陈言 李水仙 李淑霞 杜娜娜 WU Zhen;WU Hua-Yu;CAI Juan-Juan;CHEN Yan;LI Shui-Xian;LI Shu-Xia;DU Na-Na(,Department of Ophthalmology,Ophthalmology and Otorhinolaryngology Hospital of Jiaozuo,Jiaozuo 454000,Henan Province,China;Municipal Institute for Food and Drug Control of Jiaozuo,Jiaozuo 454000,Henan Province,China)

机构地区：[1]河南省焦作市五官医院眼科,454000 [2]河南省焦作市食品药物检验所,454000

出　　处：《眼科新进展》2018年第2期176-178,共3页Recent Advances in Ophthalmology

摘　　要：目的检测分析化学浸润法准分子激光上皮下角膜磨镶术弃瓣中乙醇残留含量。方法 20例40眼行准分子激光上皮下角膜磨镶术中采用体积分数20%乙醇浸润、平衡液冲洗后分离制作角膜上皮游离瓣,取出弃瓣及时密封备检,继续完成手术。观察上皮瓣制作、术后刺激症状、上皮愈合、视力恢复和术后Haze情况,检测上皮瓣中乙醇残留量。结果制作中未发生不全角膜上皮瓣。术后刺激疼痛感觉分值为(2.52±1.46)分。术后5 d新生上皮1级32眼,2级8眼。术后12周检查Haze:0.5级3眼,1级2眼。角膜上皮弃瓣中均有乙醇残留,每只弃瓣乙醇残留量(0.205 2±0.041 0)μL。结论使用乙醇浸润法经平衡液冲洗制作的上皮瓣仍含有一定量的乙醇残留,可能是术眼术后刺激症状及并发Haze的原因之一。Objective To detect and analyze of residual ethanol in abandoned flaps after laser subepithelial keratomileusis(LASEK)with ethanol infiltration methods.Methods Together 20 patients(40 eyes)undergoing LASEK were recruited in the study.After infiltrated with 20%ethanol and rinsed in equilibration solution,the corneal epithelial free flap was isolated and removed in time for sealing,and then procedures were continuously completed.Finally,observation of the skin flap production,postoperative irritation symptoms,epithelial healing,visual recovery and postoperative haze situation was performed,and then the amount of ethanol in the epithelial flap was measured.Results There was no failure in making the intact corneal flaps.The sensory score of postoperative irritation was 2.52±1.46.Neonatal epithelial with 1 grade was observed in 32 eyes,2 grade in 8 eyes 5 days after surgery,while corneal haze with 0.5 grade was occurred in 3 eyes,1 grade in 2 eyes 12 weeks after surgery.There were ethanol residues in corneal epithelium in the abandoned flaps,with the amount of ethanol residues of(0.205 2±0.041 0)μL in each flap.Conclusion It is found that a certain amount of ethanol residue in the corneal epithelium after LASEK with ethanol infiltration equilibration solution rinse,which may be one reason of the corneal irritation symptoms and corneal haze.

关 键 词：准分子激光上皮下角膜磨镶术 角膜刺激症状 角膜上皮下混浊 乙醇 

分 类 号：R778.1[医药卫生—眼科]