一个有机化学实验:萘酰亚胺化合物的合成  

A University Organic Chemistry Experiment: Synthesis of N-butyl-4,5-dihydrazine-1,8-naphthalimide

作　　者：白翠冰 熊文章[1] 乔瑞[1] 杨松[1] 刘鹏德 魏影[1] BAI Cui-bing;XIONG Wen-zhang;QIAO Rui;YANG Song;LIU Peng-de;WEI Ying(College of Chemistry and Material Engineer,Fuyang Normal University,Anhui Fuyang 236041,China)

机构地区：[1]阜阳师范学院化学与材料工程学院,安徽阜阳236041

出　　处：《广州化工》2018年第2期131-132,178,共3页GuangZhou Chemical Industry

基　　金：国家自然科学基金项目(21302019);安徽省高校优秀拔尖人才培育资助项目(gxzq ZD2017068);安徽省大学生创新创业训练计划(201610371046);阜阳师范学院本科教学质量工程项目(2015JYXM01;2016JYXM32);阜阳师范学院自然科学研究重点项目(2017FSKJ06ZD)

摘　　要：介绍一个面向大学高年级本科生的综合性有机化学实验——N-丁基-4,5-二肼基-1,8-萘酰亚胺的合成与结构表征。以苊为起始原料,经过多步反应,结合层析法、重结晶等多种分离手段,最终得到目标化合物,并利用熔点测定、红外光谱和核磁共振氢谱等表征手段确定了目标化合物和中间产物的结构。该实验路线成熟可靠,涉及多种反应类型,可以检验学生理论水平和训练学生实验技能,培养学生发现问题和解决问题的能力,是一个值得推荐的有机化学实验。The synthesis and characterization of N-butyl-4,5-dihydrazine-1,8-naphthalimide is an exploratory experiment completed by senior undergraduates.N-butyl-4,5-dihydrazine-1,8-naphthalimide was obtained by nitration,bromination,oxidation and substitution with acenaphthene as raw material.And the target compound was separated through chromatography and recrystallization.By the way of melting point,IR and 1 H-NMR,the character of the compounds were confirmed.It was proposed as an Organic Chemistry experiment as it contained coupling reaction,which would be beneficial for testing theoretical level,improving the synthesis ability of students and cultivating their ability of finding and resolving problems.

关 键 词：萘酰亚胺 红外光谱:核磁共振氢谱 亲电取代 缩合反应 亲核取代 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]