MicroRNA-31在上皮性卵巢癌中的表达及其与预后的关系  

Relationship between miR-31 expression and prognosis of patients with epithelial ovarian cancer

作　　者：徐志宏[1] 吴小华 姚铁柱[3] 梁秀琴 Zhi-hong Xu;Xiao-hua Wu;Tie-zhu Yao;Xiu-qin Liang(Department of Oncology,the Fourth Hospital of Hebei Medical University,Shijiazhuang,Hebei 050011,China;Department of Gynaecology and Obstetrics,Bethune International Peace Hospital,Shijiazhuang,Hebei 050000,China;Department of Cardiology,the Fourth Hospital of Hebei Medical University,Shijiazhuang,Hebei 050011,China;Department of Gynaecology and Obstetrics,the Seventh Hospital of Baoding,Baoding,Hebei 071000,China)

机构地区：[1]河北医科大学第四医院肿瘤内科,河北石家庄050011 [2]白求恩国际和平医院妇产科,河北石家庄050000 [3]河北医科大学第四医院心内科,河北石家庄050011 [4]河北省保定第七医院妇产科,河北保定071000

出　　处：《中国现代医学杂志》2018年第4期35-38,共4页China Journal of Modern Medicine

基　　金：河北省卫生厅医学科学研究重点课题(No:20160657)

摘　　要：目的本研究旨在探讨microRNA-31(miR-31)在上皮性卵巢癌(EOC)中的表达水平与临床病理学因素以及预后的关系。方法采用实时荧光定量聚合酶链反应(qRT-PCR)检测150例EOC患者组织中miR-31的表达水平,将miR-31表达情况与随访结果和临床资料相结合进行统计学分析。结果在EOC组织中miR-31的表达较癌旁正常卵巢组织降低(P<0.05)。miR-31的低表达与较差的组织学分级、较多的淋巴结转移、更广泛的腹膜转移和更晚期的病理分期有关(P<0.05),而与其他临床病理学因素无关(P>0.05)。此外,miR-31的表达是患者总生存的独立预测因子。结论 miR-31可能是EOC一个新的诊断和预后标志物。Objective To investigate the expression of miR-31 in epithelial ovarian cancer(EOC),and analyze the relationship of its expression with clinicopathological features and prognosis.Methods qRT-PCR was performed to detect miR-31 expression in the EOC tissues.The correlations of miR-31 expression with follow-up results and clinicopathological factors of the EOC patients were analyzed.Results The expression of miR-31 in the EOC tissues was reduced significantly compared with the adjacent normal tissues(P<0.05).Low expression of miR-31 was correlated with higher histological grade,lymph node metastasis,peritoneal metastasis,and higher FIGO stage(P<0.05),but was irrelevant with other clinical pathological factors(P>0.05).In addition,the expression of miR-31 was an independent prognostic factor for overall survival of the patients.Conclusions It is possible that miR-31 serves as a diagnostic and prognostic marker in clinical practice.

关 键 词：miR-31 临床病理学 上皮性卵巢癌 预后 

分 类 号：R737.31[医药卫生—肿瘤]