P53、Her-2和Ki67在甲状腺乳头状癌中的表达及其临床意义  

Expressions of p53, Her-2 and Ki67 in thyroid papillary carcinoma and their clinical significance

作　　者：贾巍[1] 尹长恒[1] Wei Jia;Chang-heng Yin(Harrison International Peace Hospital,Hengshui,Hebei 053000,China)

机构地区：[1]哈励逊国际和平医院,河北衡水053000

出　　处：《中国现代医学杂志》2018年第5期33-37,共5页China Journal of Modern Medicine

基　　金：河北省衡水市科技局科研基金(No:14021A)

摘　　要：目的探讨P53、Her-2和Ki67在甲状腺乳头状癌中的表达及临床意义。方法采用免疫组织化学法,分别研究128例甲状腺乳头状癌肿瘤组织,56例甲状腺腺瘤组织,以及9例正常甲状腺组织标本中P53、Her-2和Ki67的表达。结果 P53、Her-2和Ki67在正常甲状腺组织中无阳性表达。甲状腺乳头状癌组织中P53阳性表达率为85.15%(109/128),高于腺瘤组织的26.78%(15/56)(P<0.05)。甲状腺乳头状癌组织中Her-2阳性表达率为25.78%(33/128),高于腺瘤组织的12.49%(7/56)(P<0.05)。甲状腺乳头状癌和腺瘤组织中的Ki67阳性率分别为38.28%(49/128)和23.21%(13/56),差异无统计学意义(P>0.05)。结论 P53、Her-2对临床评估甲状腺乳头状癌的发生、发展及预后有一定指导意义,Ki67对鉴别甲状腺乳头状癌无明确临床意义。Objective To investigate the expressions of p53,Her-2 and Ki67 in thyroid papillary carcinomas(TPC)and their significance.Methods The expressions of p53,Her-2 and Ki67 in 128 cases of TPC,56 cases of thyroid adenomas and 9 cases of normal thyroid tissues were detected by immunohistochemical technique.Results There was no positive expression of p53,Her-2 or Ki67 in the normal thyroid tissues.The positive expression rate of p53 in the TPC was 85.15%(109/128)which was significantly higher than 26.78%(15/56)of the thyroid adenomas(P<0.05).The positive expression rate of Her-2 in the TPC was 25.78%(33/128)which was significantly higher than 12.49%(7/56)of the thyroid adenomas(P<0.05).The positive rates of Ki67 expression in the TPC and the thyroid adenomas were 38.28%(49/128)and 23.21%(13/56)respectively,the statistical analysis showed no significant difference between the two groups(P>0.05).Conclusions P53 and Her-2 expressions have certain guiding significance for the evaluation of the occurrence,development and prognosis of thyroid papillary carcinoma.Ki67 has no definite clinical significance in differential diagnosis of TPC.

关 键 词：乳头状癌 抗癌基因 人类表皮生长因子受体2 细胞增殖抗原 

分 类 号：R736.1[医药卫生—肿瘤]