乳腺癌中HES1的表达情况及与生存预后的相关性  

HES1 expression and its correlation with prognosis in breast cancer

作　　者：李晓瑛[1] 曹彧[1] 金锋[1] Li Xiaoying;Cao Yu;Jin Feng(Department of Breast Surgery,The First Affiliated Hospital of China Medical University,Liaoning Shenyang 110001,China)

机构地区：[1]中国医科大学附属第一医院乳腺外科一病区,辽宁沈阳110001

出　　处：《现代肿瘤医学》2018年第6期872-875,共4页Journal of Modern Oncology

摘　　要：目的:研究HES1在乳腺癌中的表达情况,探讨其与乳腺癌生存预后的关系。方法:采用免疫组化及Western blot检测了HES1在115例乳腺癌中的表达情况,应用Kaplan-Meier生存统计学方法分析HES1与乳腺癌生存预后的相关性。结果:在乳腺癌中,HES1阳性表达与TNM高分期(P=0.003)、淋巴结转移(P=0.043)、ER阴性(P=0.001)、PR阴性(P=0.042)及三阴性类型(P=0.001)均呈显著的相关性。此外,115例乳腺癌中HES1阳性表达组其无进展生存期(P=0.005)和总生存期(P=0.001)明显少于HES1阴性表达组。结论:HES1可能是乳腺癌的一个独立预后指标。Objective:To examine the expression pattern and biological roles of HES1 in breast cancers and to explore the relationship of HES1 and prognosis in breast cancers.Methods:We examined HES1 expression in 115 breast cancer tissues using immunohistochemistry and Western blot analyses.Correlation between HES1 expression and prognosis in breast cancers was analyzed by Kaplan-Meier analysis.Results:A significant association was found between HES1 overexpression and advanced TNM stage(P=0.003),nodal metastasis(P=0.043),negative estrogen receptor expression(P=0.001),negative progesterone receptor expression(P=0.042)and triple-negative status(P=0.001).Positive HES1 expression was associated with lower progression-free survival(P=0.005)and overall survival(P=0.001)in breast cancer patients.Conclusion:HES1 may be an independent prognostic factor for breast cancers.

关 键 词：HES1 乳腺癌 预后 

分 类 号：R737.9[医药卫生—肿瘤]