1081例患者宫颈HR-HPV感染情况分析  

The investigation of high-risk human papil omavirus infection in cervix of 1081 women

作　　者：周琴[1] 钱文艳[1] 朱艳[1] 江雯波[1] 顾雪芳[1] 邬素芳 Zhou Qin;Qian Wenyan;Zhu Yan;Jiang Wenbo;Gu Xuefang;Wu Sufang(Department of Gynecology,Kunshan Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Jiangsu Kunshan 215300,China;Department of Gynecology,Shanghai General Hospital,Shanghai 201600,China)

机构地区：[1]南京中医药大学附属昆山市中医医院妇科,江苏昆山215300 [2]上海第一人民医院妇科,上海201600

出　　处：《现代肿瘤医学》2018年第6期917-919,共3页Journal of Modern Oncology

摘　　要：目的:了解一年内昆山市中医医院妇科就诊的患者宫颈各级病变中高危型人乳头瘤病毒(HRHPV)感染情况及昆山地区妇女未来接种HPV疫苗的类型。方法:回顾性分析2015年7月至2016年7月昆山市中医医院妇科门诊接受宫颈癌三阶梯筛查中具有宫颈活检病理检查结果且HR-HPV阳性的1 081例患者。结果:宫颈炎症的患者共927例,以HPV52亚型最普遍;低级别宫颈鳞状上皮内病变共66例,HPV51、HPV52两种亚型常见。高级别宫颈鳞状上皮内病变及宫颈癌共88例,以HPV16亚型最常见。据宫颈组织病理学,单一HPV感染与多重HPV感染在宫颈各级病变中差异无统计学意义。结论:HPV52亚型是昆山地区生育期女性宫颈HPV感染最常见的类型。宫颈病变级别与HPV感染类型数目无关,即多重HPV同时感染不加重宫颈病变的进展。Objective:To investigate the prevalence of high-risk human papillomavirus in cervix of women from Kunshan Hospital of Traditional Chinese Medicine in the past year,and to evaluate the application of the type of HPV vaccination of in Kunshan region.Methods:We reviewed retrospectively the prevalence of high-risk HPV infection among 1081 patients who accepted the three-step cervical cancer screening,cytology-colposcopy-histology,from July 2015 to July 2016.Results:HPV52 was the most common type in cervical inflammation,while,HPV16 was the commonest in high level squamous cervical intraepithelial neoplasia.According to the cervical histopathology,the difference between a single genotype of HR-HPV infection and multiple genotypes of HR-HPV infection had no statistically significance in the cervical lesions at all levels.Conclusion:HPV52 is the most frequently cervical infection genotype of women in Kunshan rigion.The cervical lesion level is irrelevant with the number of HR-HPV infection type,which indicates multiple genotypes of HR-HPV infection do not increase the development of cervical disease.

关 键 词：高危型人乳头瘤病毒 基因分型 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]