抑癌基因DACH1在食管癌变中甲基化的改变及其表达调控的研究进展  

The methylation of anti-oncogene DACH1 in esophageal carcinogenesis and its regulation

作　　者：张晨 田霖丽[1] 刘鸣[1] Zhang Chen;Tian Linli;Liu Ming(Department of Otorhinolaryngology Head and Neck Surgery,The Second Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150000,China)

机构地区：[1]哈尔滨医科大学附属第二医院耳鼻咽喉头颈外科,黑龙江哈尔滨150000

出　　处：《现代肿瘤医学》2018年第6期965-967,共3页Journal of Modern Oncology

摘　　要：由于多种癌基因、抑癌基因参与肿瘤发生、发展过程,癌基因/抑癌基因的持续性改变,导致了食管局部累积性改变,最终形成食管恶性肿瘤。本文针对DACH1在食管癌变中的甲基化改变及其表达调控的研究进行综述。With participation of various oncogenes and tumor suppressor genes involved in genesis and development,and continuous changes oncogene/tumor suppressor genes,leading to a cumulative change and the final formation of esophageal cancer.The paper related to the methylation and regulation of DACH1 in esophageal cancer are reviewed.

关 键 词：DACH1 食管癌 癌变甲基化改变 表达调控 

分 类 号：R735.1[医药卫生—肿瘤]