COPD相关性腺癌与鳞癌基因遗传差异的研究进展  

Research progress on genetic diversity of COPD-related adenocarcinoma and COPD-related squamous cell carcinoma

作　　者：方启宇[1] 邓沁芳[1] 孟淑燕[1] 周崧雯[1] Fang Qiyu;Deng Qinfang;Meng Shuyan;Zhou Songwen(Department of Medical Oncology,Shanghai Pulmonary Hospital,Tongji University School of Medicine,Shanghai 200433,China)

机构地区：[1]同济大学附属上海市肺科医院肿瘤科,上海200433

出　　处：《现代肿瘤医学》2018年第6期975-979,共5页Journal of Modern Oncology

摘　　要：在世界范围内,肺癌是癌症死亡的主要原因。其中非小细胞肺癌占85%,主要病理类型为腺癌和鳞癌。研究提示COPD独立于吸烟,为其高危因素。相同的致病因子作用下,COPD相关性腺癌与鳞癌的差异提示,两者之间除常见的慢性炎症、氧化应激、免疫应答等机制外,还存在不同的基因遗传机制。本文就COPD相关性腺癌和COPD相关性鳞癌基因遗传关系的研究进展作一综述。Lung cancer is the leading cause of death from cancer worldwide,where non-small-cell lung cancers(NSCLCs)represent 85%of all lung cancers.Independent of smoking,chronic obstructive pulmonary disease(COPD)patients have an increased risk of NSCLCs which consist of adenocarcinoma and squamous cell carcinoma primarily.According to the distinction between COPD-related adenocarcinoma and COPD-related squamous cell carcinoma,genetic mechanism plays an important role in the development besides common causes as chronic inflammation,oxidative stress,immune response mechanism in the same causative agent.This revie

关 键 词：慢性阻塞性肺病 腺癌 鳞癌 基因 

分 类 号：R734.2[医药卫生—肿瘤]