高压氧治疗中老年急性脑梗死的临床疗效及对患者巨噬细胞集落刺激因子、氧化修饰低密度脂蛋白、可溶性细胞黏附因子-1的影响  

Influence of hyperbaric oxygen therapy for middle aged and elderly patients with acute cerebral infarction and its effect on M-CSF,ox-LDL and sICAM-1

作　　者：周宏[1] 叶淑萍[1] 王丽靖[1] ZHOU Hong;YE Shuping;WANG Lijing(Department of Neurology,Beijing Fengtai Hospital,Beijing,100070)

机构地区：[1]北京丰台医院神经内科,北京100070

出　　处：《实用临床医药杂志》2018年第3期9-11,15,共4页Journal of Clinical Medicine in Practice

基　　金：北京市科技计划项目(D111107003111006)

摘　　要：目的分析高压氧治疗中老年急性脑梗死的临床疗效及对患者巨噬细胞集落刺激因子(M-CSF)、氧化修饰低密度脂蛋白(ox-LDL)、可溶性细胞黏附因子-1(s ICAM-1)的影响。方法选取本院接受诊治的100例中老年人急性脑梗死患者作为研究对象,根据随机数表法分为对照组、研究组,各50例。对照组患者采用常规治疗方法,研究组患者采用高压氧治疗方法。比较2组患者治疗前后血清指标、神经缺损功能及脑血流量(CBF)、脑血容量(CBV)情况。结果治疗后,2组患者M-CSF、ox-LDL、s ICAM-1水平均低于治疗前,且研究组低于对照组(P<0.05);研究组患者治疗总有效率高于对照组(P<0.05);治疗后2组患者CBF、CBV水平均高于治疗前,且研究组高于对照组(P<0.05)。结论采用高压氧治疗中老年急性脑梗死效果显著,能有效降低M-CSF、ox-LDL、s ICAM-1的表达,减少患者脑血管损伤,抑制血栓的形成,改善患者神经缺损功能,缓解脑组织血氧供应不足,值得临床推广。Objective To study the clinical efficacy of hyperbaric oxygen therapy in the treatment of middle-aged and elderly patients with acute cerebral infarction and their effects on M-CSF,ox-LDL and sICAM-1.Methods A total of 100 elderly patients with acute cerebral infarction who were treated in our hospital were divided into control group and study group according to the random number table method,with 50 cases in each group.The patients in the control group were treated with conventional therapy,and the patients in the study group were treated with hyperbaric oxygen therapy.The levels of serum markers,nerve defect function and cerebral cerebral blood flow(CBF),cerebral blood volume(CBV)were observed and compared between the two groups before and after treatment.Results After treatment,the levels of M-CSF,ox-LDL and sICAM-1 in the two groups were lower than treatment before,and study group was lower than the control group(P<0.05);The total clinical outcomes was higher in the study group than that in the control group(P<0.05).After treatment,the CBF and CBV levels of the two groups were higher than treatment before,and the study group was higher than the control group(P<0.05).Conclusion Hyperbaric oxygen therapy in the treatment of the elderly with acute cerebral infarction can effectively reduce the expression of M-CSF,ox-LDL,sICAM-1,reduce cerebral vascular injury,inhibit the formation of thrombosis,improve the function of nerve deficit,relieve the insufficient of oxygen supply,so it is worthy of clinical promotion.

关 键 词：高压氧 急性脑梗死 巨噬细胞集落刺激因子 氧化修饰低密度脂蛋白 可溶性细胞黏附因子-1 

分 类 号：R743[医药卫生—神经病学与精神病学]